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10.1186/s12575-021-00145-9 http://scihub22266oqcxt.onion/10.1186/s12575-021-00145-9 33618659!7899210!33618659     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Proced+Online 2021 ; 23 (1): 8 Nephropedia Template TP {{tp|p=33618659|t=2021. Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2 |pdf=|usr=}}{{33618659}} gab.com Text Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2 JO: Biol Proced Online http://www.kidney.de/pget.php?&tw=1&pmid=33618659 #FOAvip The proteostasis network includes all the factors that control the function of proteins in their native state and minimize their non-functional or harmful reactions. The molecular chaperones, the important mediator in the proteostasis network can be considered as any protein that contributes to proper folding and assembly of other macromolecules, through maturating of unfolded or partially folded macromolecules, refolding of stress-denatured proteins, and modifying oligomeric assembly, otherwise it leads to their proteolytic degradation. Viruses that use the hosts' gene expression tools and protein synthesis apparatus to survive and replicate, are obviously protected by such a host chaperone system. This means that many viruses use members of the hosts' chaperoning system to infect the target cells, replicate, and spread. During viral infection, increase in endoplasmic reticulum (ER) stress due to high expression of viral proteins enhances the level of heat shock proteins (HSPs) and induces cell apoptosis or necrosis. Indeed, evidence suggests that ER stress and the induction of unfolded protein response (UPR) may be a major aspect of the corona-host virus interaction. In addition, several clinical reports have confirmed the autoimmune phenomena in COVID-19-patients, and a strong association between this autoimmunity and severe SARS-CoV-2 infection. Part of such autoimmunity is due to shared epitopes among the virus and host. This article reviews the proteostasis network and its relationship to the immune system in SARS-CoV-2 infection. Twit Text FOAVip Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2 ????Biol Proced Online http://www.kidney.de/pget.php?&tw=1&pmid=33618659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33618659 #FOAvip English Wikipedia <ref>{{Cite pmid|33618659}}</ref> Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2 #MMPMID33618659 Khomari F; Nabi-Afjadi M; Yarahmadi S; Eskandari H; Bahreini E Biol Proced Online 2021[Feb]; 23 (1): 8 PMID33618659show ga The proteostasis network includes all the factors that control the function of proteins in their native state and minimize their non-functional or harmful reactions. The molecular chaperones, the important mediator in the proteostasis network can be considered as any protein that contributes to proper folding and assembly of other macromolecules, through maturating of unfolded or partially folded macromolecules, refolding of stress-denatured proteins, and modifying oligomeric assembly, otherwise it leads to their proteolytic degradation. Viruses that use the hosts' gene expression tools and protein synthesis apparatus to survive and replicate, are obviously protected by such a host chaperone system. This means that many viruses use members of the hosts' chaperoning system to infect the target cells, replicate, and spread. During viral infection, increase in endoplasmic reticulum (ER) stress due to high expression of viral proteins enhances the level of heat shock proteins (HSPs) and induces cell apoptosis or necrosis. Indeed, evidence suggests that ER stress and the induction of unfolded protein response (UPR) may be a major aspect of the corona-host virus interaction. In addition, several clinical reports have confirmed the autoimmune phenomena in COVID-19-patients, and a strong association between this autoimmunity and severe SARS-CoV-2 infection. Part of such autoimmunity is due to shared epitopes among the virus and host. This article reviews the proteostasis network and its relationship to the immune system in SARS-CoV-2 infection. äEffects of Cell Proteostasis Network on the Survival of SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing