Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4149/BLL_2021_035 http://scihub22266oqcxt.onion/10.4149/BLL_2021_035 33618530!ä!33618530 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bratisl+Lek+Listy 2021 ; 122 (3): 206-211 Nephropedia Template TP {{tp|p=33618530|t=2021. Potential therapeutic road for targeting the SARS-CoV-2 at throat |pdf=|usr=}}{{33618530}} gab.com Text Potential therapeutic road for targeting the SARS-CoV-2 at throat JO: Bratisl Lek Listy http://www.kidney.de/pget.php?&tw=1&pmid=33618530 #FOAvip INTRODUCTION: Coronavirus disease 2019 (COVID-19) has become a serious public health problem for 183 out of 197 countries in the world. Understanding the routes and pathogenesis of the coronavirus is important and it is considered that the studies on host cell receptor Angiotensin Converting Enzyme 2 (ACE2) may be valuable for the treatment and prevention of the disease. AIM: To evaluate the possibility of inhibition of SARS-CoV-2 at throat. METHODS: A comprehensive literature search was conducted. CONCLUSION: In view of the fact that the mouth and nose have higher number of ACE2 expressed cells, they serve as a gateway for the virus to enter. Thus, blocking the gate could be a good choice to reduce or even prevent the transmission. Small interfering RNAs (siRNAs) are double-stranded RNA molecules and could be designed easily and directed against many strains of a virus. Due to their features, siRNAs can provide a potential strategy to interfere with the replication of viral diseases. We think that since oral and nasal epithelial cells are relatively easily accessible it may allow to develop siRNA molecules to inhibit SARS-CoV-2 already at the entry where it continues to replicate for a period (Fig. 1, Ref. 50). Twit Text FOAVip Potential therapeutic road for targeting the SARS-CoV-2 at throat ????Bratisl Lek Listy http://www.kidney.de/pget.php?&tw=1&pmid=33618530 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33618530 #FOAvip English Wikipedia <ref>{{Cite pmid|33618530}}</ref> Potential therapeutic road for targeting the SARS-CoV-2 at throat #MMPMID33618530 Kaya M; Abuaisha AM; Serakinci N; Ozturk S Bratisl Lek Listy 2021[]; 122 (3): 206-211 PMID33618530show ga INTRODUCTION: Coronavirus disease 2019 (COVID-19) has become a serious public health problem for 183 out of 197 countries in the world. Understanding the routes and pathogenesis of the coronavirus is important and it is considered that the studies on host cell receptor Angiotensin Converting Enzyme 2 (ACE2) may be valuable for the treatment and prevention of the disease. AIM: To evaluate the possibility of inhibition of SARS-CoV-2 at throat. METHODS: A comprehensive literature search was conducted. CONCLUSION: In view of the fact that the mouth and nose have higher number of ACE2 expressed cells, they serve as a gateway for the virus to enter. Thus, blocking the gate could be a good choice to reduce or even prevent the transmission. Small interfering RNAs (siRNAs) are double-stranded RNA molecules and could be designed easily and directed against many strains of a virus. Due to their features, siRNAs can provide a potential strategy to interfere with the replication of viral diseases. We think that since oral and nasal epithelial cells are relatively easily accessible it may allow to develop siRNA molecules to inhibit SARS-CoV-2 already at the entry where it continues to replicate for a period (Fig. 1, Ref. 50). |*COVID-19[MESH] |*Coronavirus Infections[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A/genetics[MESH] |Pharynx[MESH]Potential therapeutic road for targeting the SARS-CoV-2 at throat (epmc).pdf DeepDyve Pubget Overpricing