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10.1016/j.ejmech.2021.113294 http://scihub22266oqcxt.onion/10.1016/j.ejmech.2021.113294 33618158!7880840!33618158     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Med+Chem 2021 ; 215 (ä): 113294 Nephropedia Template TP {{tp|p=33618158|t=2021. Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?|pdf=|usr=}}{{33618158}} gab.com Text Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors JO: Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33618158 #FOAvip The fascinating similarity between the SARS-CoV and SARS-CoV-2, inspires scientific community to investigate deeper into the SARS-CoV proteases such as main protease (Mpro) and papain-like protease (PLpro) and their inhibitors for the discovery of SARS-CoV-2 protease inhibitors. Because of the similarity in the proteases of these two corona viruses, there is a greater chance for the previous SARS-CoV Mpro and PLpro inhibitors to provide effective results against SARS-CoV-2. In this context, the molecular fragments from the SARS-CoV protease inhibitors through the fragment-based drug design and discovery technique can be useful guidance for COVID-19 drug discovery. Here, we have focused on the structure-activity relationship studies of previous SARS-CoV protease inhibitors and discussed about crucial fragments generated from previous SARS-CoV protease inhibitors important for the lead optimization of SARS-CoV-2 protease inhibitors. This study surely offers different strategic options of lead optimization to the medicinal chemists to discover effective anti-viral agent against the devastating disease, COVID-19. Twit Text FOAVip Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors ????Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33618158 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33618158 #FOAvip English Wikipedia <ref>{{Cite pmid|33618158}}</ref> Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors? #MMPMID33618158 Amin SA; Banerjee S; Gayen S; Jha T Eur J Med Chem 2021[Apr]; 215 (ä): 113294 PMID33618158show ga The fascinating similarity between the SARS-CoV and SARS-CoV-2, inspires scientific community to investigate deeper into the SARS-CoV proteases such as main protease (Mpro) and papain-like protease (PLpro) and their inhibitors for the discovery of SARS-CoV-2 protease inhibitors. Because of the similarity in the proteases of these two corona viruses, there is a greater chance for the previous SARS-CoV Mpro and PLpro inhibitors to provide effective results against SARS-CoV-2. In this context, the molecular fragments from the SARS-CoV protease inhibitors through the fragment-based drug design and discovery technique can be useful guidance for COVID-19 drug discovery. Here, we have focused on the structure-activity relationship studies of previous SARS-CoV protease inhibitors and discussed about crucial fragments generated from previous SARS-CoV protease inhibitors important for the lead optimization of SARS-CoV-2 protease inhibitors. This study surely offers different strategic options of lead optimization to the medicinal chemists to discover effective anti-viral agent against the devastating disease, COVID-19. |Antiviral Agents/*chemistry/metabolism[MESH] |Coronavirus 3C Proteases/antagonists & inhibitors/metabolism[MESH] |Coronavirus Papain-Like Proteases/antagonists & inhibitors/metabolism[MESH] |Cysteine Proteinase Inhibitors/*chemistry/metabolism[MESH] |Drug Design[MESH] |Drug Discovery[MESH] |Molecular Docking Simulation[MESH] |Molecular Structure[MESH] |Protein Binding[MESH] |SARS-CoV-2/drug effects[MESH] |Severe acute respiratory syndrome-related coronavirus/drug effects[MESH]Protease targeted COVID-19 drug discovery: What we have learned from t(epmc).pdf DeepDyve Pubget Overpricing