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10.1111/vco.12689 http://scihub22266oqcxt.onion/10.1111/vco.12689 33617107!8453503!33617107     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33617107&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Vet+Comp+Oncol 2021 ; 19 (3): 510-517 Nephropedia Template TP {{tp|p=33617107|t=2021. Expression and prognostic value of TRPM7 in canine mammary tumours |pdf=|usr=}}{{33617107}} gab.com Text Expression and prognostic value of TRPM7 in canine mammary tumours JO: Vet Comp Oncol http://www.kidney.de/pget.php?&tw=1&pmid=33617107 #FOAvip Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca(2+) and Mg(2+) permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki-67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease-free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs. Twit Text FOAVip Expression and prognostic value of TRPM7 in canine mammary tumours ????Vet Comp Oncol http://www.kidney.de/pget.php?&tw=1&pmid=33617107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33617107 #FOAvip English Wikipedia <ref>{{Cite pmid|33617107}}</ref> Expression and prognostic value of TRPM7 in canine mammary tumours #MMPMID33617107 Lee S; Lee S; Kim WH Vet Comp Oncol 2021[Sep]; 19 (3): 510-517 PMID33617107show ga Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca(2+) and Mg(2+) permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki-67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease-free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs. |*Dog Diseases/diagnosis[MESH] |*Mammary Neoplasms, Animal/diagnosis[MESH] |*TRPM Cation Channels/genetics[MESH] |Animals[MESH] |Dogs[MESH] |Female[MESH] |Prognosis[MESH]Expression and prognostic value of TRPM7 in canine mammary tumours (epmc).pdf DeepDyve Pubget Overpricing