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10.1007/s00415-021-10458-0

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33616739!7897737!33616739
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suck abstract from ncbi


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pmid33616739      J+Neurol 2021 ; 268 (10): 3517-3548
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  • Myoclonus and cerebellar ataxia associated with COVID-19: a case report and systematic review #MMPMID33616739
  • Chan JL; Murphy KA; Sarna JR
  • J Neurol 2021[Oct]; 268 (10): 3517-3548 PMID33616739show ga
  • BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic in December 2019, neurological manifestations have been recognized as potential complications. Relatively rare movement disorders associated with COVID-19 are increasingly reported in case reports or case series. Here, we present a case and systematic review of myoclonus and cerebellar ataxia associated with COVID-19. METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline using the PubMed and Ovid MEDLINE databases, from November 1, 2019 to December 6, 2020. RESULTS: 51 cases of myoclonus or ataxia associated with COVID-19, including our case, were identified from 32 publications. The mean age was 59.6 years, ranging from 26 to 88 years, and 21.6% were female. Myoclonus was multifocal or generalized and had an acute onset, usually within 1 month of COVID-19 symptoms. Myoclonus occurred in isolation (46.7%), or with ataxia (40.0%) or cognitive changes (30.0%). Most cases improved within 2 months, and treatment included anti-epileptic medications or immunotherapy. Ataxia had an acute onset, usually within 1 month of COVID-19 symptoms, but could be an initial symptom. Concurrent neurological symptoms included cognitive changes (45.5%), myoclonus (36.4%), or a Miller Fisher syndrome variant (21.2%). Most cases improved within 2 months, either spontaneously or with immunotherapy. CONCLUSIONS: This systematic review highlights myoclonus and ataxia as rare and treatable post-infectious or para-infectious, immune-mediated phenomena associated with COVID-19. The natural history is unknown and future investigation is needed to further characterize these movement disorders and COVID-19.
  • |*COVID-19[MESH]
  • |*Cerebellar Ataxia/complications[MESH]
  • |*Myoclonus/etiology[MESH]
  • |Ataxia/complications[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]


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