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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Pharmacol 2020 ; 11 (ä): 609592 Nephropedia Template TP
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Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro #MMPMID33613282
Xiong HL; Cao JL; Shen CG; Ma J; Qiao XY; Shi TS; Ge SX; Ye HM; Zhang J; Yuan Q; Zhang TY; Xia NS
Front Pharmacol 2020[]; 11 (ä): 609592 PMID33613282show ga
To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 muM.