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10.1007/s12268-021-1516-6

http://scihub22266oqcxt.onion/10.1007/s12268-021-1516-6
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33612990!7880636!33612990
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suck abstract from ncbi


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pmid33612990      Biospektrum+(Heidelb) 2021 ; 27 (1): 49-53
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  • Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir #MMPMID33612990
  • Cramer P; Kokic G; Dienemann C; Hobartner C; Hillen HS
  • Biospektrum (Heidelb) 2021[]; 27 (1): 49-53 PMID33612990show ga
  • Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 polymerase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme synthesizes RNA and how it replicates the exceptionally large genome in a processive manner. The most recent structure-function studies further reveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19.
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