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10.3906/sag-2012-5

http://scihub22266oqcxt.onion/10.3906/sag-2012-5
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33611869!8569786!33611869
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suck abstract from ncbi


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pmid33611869      Turk+J+Med+Sci 2021 ; 51 (4): 1615-1623
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  • Preferences of inflammatory arthritis patients for biological disease-modifying antirheumatic drugs in the first 100 days of the COVID-19 pandemic #MMPMID33611869
  • Kalyoncu U; Pehlivan Y; Akar S; Kasifoglu T; Kimyon G; Karadag O; Dalkilic HE; Ertenli AI; Kilic L; Ersozlu D; Bes C; Emmungil H; Mercan R; Ediboglu ED; Kanitez N; Bilgin E; Colak S; Koca SS; Gonullu E; Kucuksahin O; Coskun N; Yagiz B; Kiraz S
  • Turk J Med Sci 2021[Aug]; 51 (4): 1615-1623 PMID33611869show ga
  • BACKGROUND/AIM: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. MATERIALS AND METHODS: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of COVID-19, the rate of continuation on bDMARDs, the reasons for treatment discontinuation, if any, and the current general disease activity (visual analog scale, [VAS]). RESULTS: A total of 1394 patients (493 RA [47.3% on anti-TNF] patients and 901 SpA [90.0% on anti-TNF] patients) were included in the study. Overall, 2.8% of the patients had symptoms suggesting COVID-19, and 2 (0.15%) patients had PCR-confirmed COVID-19. Overall, 18.1% of all patients (13.8% of the RA and 20.5% of the SpA; p = 0.003) discontinued their bDMARDs. In the SpA group, the patients who discontinued bDMARDs were younger (40 [21-73] vs. 44 years [20-79]; p = 0.005) and had higher general disease activity; however, no difference was relevant for RA patients. CONCLUSION: Although the COVID-19 was quite uncommon in the first 100 days of the pandemic, nearly one-fifth of the patients discontinued bDMARDs within this period. The long-term effects of the pandemic should be monitored.
  • |*COVID-19[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antirheumatic Agents/*therapeutic use[MESH]
  • |Arthritis, Rheumatoid/*drug therapy[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Medication Adherence/*statistics & numerical data[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prospective Studies[MESH]
  • |Registries[MESH]
  • |SARS-CoV-2[MESH]


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