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10.1016/j.ijid.2021.02.059 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.02.059 33610776!7891043!33610776     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 105 (ä): 333-336 Nephropedia Template TP {{tp|p=33610776|t=2021. Assessment of commercial SARS-CoV-2 antibody assays, Jamaica |pdf=|usr=}}{{33610776}} gab.com Text Assessment of commercial SARS-CoV-2 antibody assays, Jamaica JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33610776 #FOAvip BACKGROUND: The performance of the Roche Elecsys(R) Anti-SARS-CoV-2, Abbott Architect SARS-CoV-2 IgM, Abbott Architect SARS-CoV-2 IgG, Euroimmun SARS-CoV-2 IgA, Euroimmun SARS-CoV-2 IgG ELISA, and Trillium IgG/IgM rapid assays was evaluated in Jamaica. METHODS: Diagnostic sensitivities of the assays were assessed by testing serum samples from SARS-CoV-2 PCR-confirmed persons and diagnostic specificity was assessed by testing serum samples collected during 2018-2019 from healthy persons and from persons with antibodies to a wide range of viral infections. RESULTS: Serum samples collected >/=14 days after onset of symptoms, or an initial SARS-CoV-2 RT-PCR positive test for asymptomatics, showed diagnostic sensitivities ranging from 67.9 to 75.0% when including all possible disease severities and increased to 90.0-95.0% when examining those with moderate to critical disease. Grouping moderate to critical disease showed a significant association with a SARS-CoV-2 antibody positive result for all assays. Diagnostic specificity ranged from 96.7 to 100.0%. For all assays examined, SARS-CoV-2 real-time PCR cycle threshold (Ct) values of the initial nasopharyngeal swab sample testing positive were significantly different for samples testing antibody positive versus negative. CONCLUSIONS: These data from a predominantly African descent Caribbean population show comparable diagnostic sensitivities and specificities for all testing platforms assessed and limited utility of these tests for persons with asymptomatic and mild infections. Twit Text FOAVip Assessment of commercial SARS-CoV-2 antibody assays, Jamaica ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33610776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33610776 #FOAvip English Wikipedia <ref>{{Cite pmid|33610776}}</ref> Assessment of commercial SARS-CoV-2 antibody assays, Jamaica #MMPMID33610776 Butterfield TR; Bruce-Mowatt A; Phillips YZR; Brown N; Francis K; Brown J; Walker JP; McKnight NAL; Ehikhametalor K; Taylor DK; Bruce CA; McGrowder D; Wharfe G; Sandiford SL; Thompson TK; Anzinger JJ Int J Infect Dis 2021[Apr]; 105 (ä): 333-336 PMID33610776show ga BACKGROUND: The performance of the Roche Elecsys(R) Anti-SARS-CoV-2, Abbott Architect SARS-CoV-2 IgM, Abbott Architect SARS-CoV-2 IgG, Euroimmun SARS-CoV-2 IgA, Euroimmun SARS-CoV-2 IgG ELISA, and Trillium IgG/IgM rapid assays was evaluated in Jamaica. METHODS: Diagnostic sensitivities of the assays were assessed by testing serum samples from SARS-CoV-2 PCR-confirmed persons and diagnostic specificity was assessed by testing serum samples collected during 2018-2019 from healthy persons and from persons with antibodies to a wide range of viral infections. RESULTS: Serum samples collected >/=14 days after onset of symptoms, or an initial SARS-CoV-2 RT-PCR positive test for asymptomatics, showed diagnostic sensitivities ranging from 67.9 to 75.0% when including all possible disease severities and increased to 90.0-95.0% when examining those with moderate to critical disease. Grouping moderate to critical disease showed a significant association with a SARS-CoV-2 antibody positive result for all assays. Diagnostic specificity ranged from 96.7 to 100.0%. For all assays examined, SARS-CoV-2 real-time PCR cycle threshold (Ct) values of the initial nasopharyngeal swab sample testing positive were significantly different for samples testing antibody positive versus negative. CONCLUSIONS: These data from a predominantly African descent Caribbean population show comparable diagnostic sensitivities and specificities for all testing platforms assessed and limited utility of these tests for persons with asymptomatic and mild infections. |Antibodies, Viral/*blood[MESH] |COVID-19 Serological Testing/*methods[MESH] |COVID-19/blood/*diagnosis/immunology[MESH] |Caribbean Region[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Humans[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Jamaica[MESH] |SARS-CoV-2/*immunology/isolation & purification[MESH]Assessment of commercial SARS-CoV-2 antibody assays, Jamaica (epmc).pdf DeepDyve Pubget Overpricing