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10.1016/j.neurol.2021.01.004

http://scihub22266oqcxt.onion/10.1016/j.neurol.2021.01.004
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suck abstract from ncbi


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pmid33610347      Rev+Neurol+(Paris) 2021 ; 177 (3): 275-282
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  • Clinical description of the broad range of neurological presentations of COVID-19: A retrospective case series #MMPMID33610347
  • Cleret de Langavant L; Petit A; Nguyen QTR; Gendre T; Abdelhedi J; Djellaoui A; Seddik L; Lim L; Faugeras F; Salhi H; Wahab A; Fechtenbaum L; Dormeuil A; Hosseini H; Youssov K; Fenelon G; Bapst B; Brugieres P; Tuilier T; Kalsoum E; Matignon MB; Oniszczuk J; Gallien S; Vindrios W; Melica G; Scain AL; Esser R; Rostain L; Guillaud C; Dubos-Lascu G; Saada N; Guillet H; Khellaf M; Bardel B; Ayache SS; Lefaucheur JP; Pawlotsky JM; Fourati S; Bachoud-Levi AC
  • Rev Neurol (Paris) 2021[Mar]; 177 (3): 275-282 PMID33610347show ga
  • BACKGROUND: Neurological disorders associated with SARS-CoV-2 infection represent a clinical challenge because they encompass a broad neurological spectrum and may occur before the diagnosis of COVID-19. METHODS: In this monocentric retrospective case series, medical records from patients with acute neurological disorders associated with SARS-CoV-2 infection from medicine departments of an academic center in Paris area were collected between March 15(th) and May 15(th) 2020. Diagnosis of SARS-CoV-2 was ascertained through specific RT-PCR in nasopharyngeal swabs or based on circulating serum IgG antibodies. RESULTS: Twenty-six patients diagnosed with SARS-CoV-2 infection presented with neurological disorders: encephalitis (N=8), encephalopathy (N=6), cerebrovascular events (ischemic strokes N=4 and vein thromboses N=2), other central nervous system (CNS) disorders (N=4), and Guillain-Barre syndrome (N=2). The diagnosis of SARS-CoV-2 was delayed on average 1.6 days after the onset of neurological disorder, especially in case of encephalitis 3.9 days, encephalopathy 1.0 day, and cerebrovascular event 2.7 days. CONCLUSIONS: Our study confirms that COVID-19 can yield a broad spectrum of neurological disorders. Because neurological presentations of COVID-19 often occur a few days before the diagnosis of SARS-COV-2 infection, clinicians should take preventive measures such as patient isolation and masks for any new admission to avoid nosocomial infections. Anti-SARS-CoV2 antibody detection in RT-PCR SARS CoV-2 negative suspected cases is useful to confirm a posteriori the diagnosis of atypical COVID-19 presentations.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*complications/*epidemiology/psychology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nervous System Diseases/*epidemiology/*etiology/virology[MESH]
  • |Paris/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/physiology[MESH]


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