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10.1016/j.ijid.2021.02.052

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.02.052
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33609774!7888994!33609774
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suck abstract from ncbi


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pmid33609774      Int+J+Infect+Dis 2021 ; 105 (ä): 144-146
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  • Comparative evaluation of four SARS-CoV-2 antigen tests in hospitalized patients #MMPMID33609774
  • Thommes L; Burkert FR; Ottl KW; Goldin D; Loacker L; Lanser L; Griesmacher A; Theurl I; Weiss G; Bellmann-Weiler R
  • Int J Infect Dis 2021[Apr]; 105 (ä): 144-146 PMID33609774show ga
  • OBJECTIVES: Rapid identification of infected subjects is a cornerstone for controlling a pandemic like the current one with the SARS-CoV-2. Easy to handle antigen tests can provide timely results, which is of particular importance in a primary care setting. However, concerns exist regarding their sensitivity, which led us to evaluate four commercially available tests in patients hospitalized for COVID-19. METHODS: We analyzed in parallel nasopharyngeal/oropharyngeal swabs from 154 consecutive patients admitted to our department with moderate to severe COVID-19, using quantitative RT-PCR (Cobas, Roche) and up to four antigen tests from different distributors. Antigen test results were linked to Ct (cycle threshold) values as markers for patients' infectivity. RESULTS: We found that two out of four antigen tests correctly identified subjects with high viral loads (Ct30, we found that the antigen test was still positive in up to 45% of those cases. CONCLUSION: Most antigen tests had a sufficient sensitivity to identify symptomatic subjects infected with SARS-CoV-2 and with transmissible infection. On the other hand, antigen testing may not be suitable to identify loss of infectivity in COVID-19 subjects during follow-up. Newly introduced antigen tests need to be validated in a clinical or primary care setting to define their clinical usefulness.
  • |*COVID-19 Serological Testing[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antigens, Viral/*analysis[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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