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10.1016/j.lfs.2021.119245 http://scihub22266oqcxt.onion/10.1016/j.lfs.2021.119245 33609539!7889033!33609539     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 272 (ä): 119245 Nephropedia Template TP {{tp|p=33609539|t=2021. A double edged-sword - The Complement System during SARS-CoV-2 infection |pdf=|usr=}}{{33609539}} gab.com Text A double edged-sword - The Complement System during SARS-CoV-2 infection JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33609539 #FOAvip In the past 20 years, infections caused by coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 have posed a threat to public health since they may cause severe acute respiratory syndrome (SARS) in humans. The Complement System is activated during viral infection, being a central protagonist of innate and acquired immunity. Here, we report some interactions between these three coronaviruses and the Complement System, highlighting the central role of C3 with the severity of these infections. Although it can be protective, its role during coronavirus infections seems to be contradictory. For example, during SARS-CoV-2 infection, Complement System can control the viral infection in asymptomatic or mild cases; however, it can also intensify local and systemic damage in some of severe COVID-19 patients, due to its potent proinflammatory effect. In this last condition, the activation of the Complement System also amplifies the cytokine storm and the pathogenicity of coronavirus infection. Experimental treatment with Complement inhibitors has been an enthusiastic field of intense investigation in search of a promising additional therapy in severe COVID-19 patients. Twit Text FOAVip A double edged-sword - The Complement System during SARS-CoV-2 infection ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33609539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33609539 #FOAvip English Wikipedia <ref>{{Cite pmid|33609539}}</ref> A double edged-sword - The Complement System during SARS-CoV-2 infection #MMPMID33609539 Santiesteban-Lores LE; Amamura TA; da Silva TF; Midon LM; Carneiro MC; Isaac L; Bavia L Life Sci 2021[May]; 272 (ä): 119245 PMID33609539show ga In the past 20 years, infections caused by coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 have posed a threat to public health since they may cause severe acute respiratory syndrome (SARS) in humans. The Complement System is activated during viral infection, being a central protagonist of innate and acquired immunity. Here, we report some interactions between these three coronaviruses and the Complement System, highlighting the central role of C3 with the severity of these infections. Although it can be protective, its role during coronavirus infections seems to be contradictory. For example, during SARS-CoV-2 infection, Complement System can control the viral infection in asymptomatic or mild cases; however, it can also intensify local and systemic damage in some of severe COVID-19 patients, due to its potent proinflammatory effect. In this last condition, the activation of the Complement System also amplifies the cytokine storm and the pathogenicity of coronavirus infection. Experimental treatment with Complement inhibitors has been an enthusiastic field of intense investigation in search of a promising additional therapy in severe COVID-19 patients. |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/complications/*immunology/pathology[MESH] |Complement Activation/drug effects[MESH] |Complement C3/immunology[MESH] |Complement Inactivating Agents/pharmacology/therapeutic use[MESH] |Complement System Proteins/*immunology[MESH] |Coronavirus Infections/complications/drug therapy/immunology/pathology[MESH] |Cytokine Release Syndrome/complications/drug therapy/immunology/pathology[MESH] |Humans[MESH] |Inflammation/complications/drug therapy/immunology/pathology[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Severe Acute Respiratory Syndrome/complications/drug therapy/immunology/pathology[MESH]A double edged-sword - The Complement System during SARS-CoV-2 infecti(epmc).pdf DeepDyve Pubget Overpricing