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10.1007/s43440-021-00233-3

http://scihub22266oqcxt.onion/10.1007/s43440-021-00233-3
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suck abstract from ncbi


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pmid33608850      Pharmacol+Rep 2021 ; 73 (3): 769-780
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  • In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis #MMPMID33608850
  • Permana H; Huang I; Purwiga A; Kusumawardhani NY; Sihite TA; Martanto E; Wisaksana R; Soetedjo NNM
  • Pharmacol Rep 2021[Jun]; 73 (3): 769-780 PMID33608850show ga
  • BACKGROUND AND AIMS: The idea of treating COVID-19 with statins is biologically plausible, although it is still controversial. The systematic review and meta-analysis aimed to address the association between the use of statins and risk of mortality in patients with COVID-19. METHODS: Several electronic databases, including PubMed, SCOPUS, EuropePMC, and the Cochrane Central Register of Controlled Trials, with relevant keywords up to 11 November 2020, were used to perform a systematic literature search. This study included research papers containing samples of adult COVID-19 patients who had data on statin use and recorded mortality as their outcome of interest. Risk estimates of mortality in statin users versus non-statin users were pooled across studies using inverse-variance weighted DerSimonian-Laird random-effect models. RESULTS: Thirteen studies with a total of 52,122 patients were included in the final qualitative and quantitative analysis. Eight studies reported in-hospital use of statins; meanwhile, the remaining studies reported pre-admission use of statins. In-hospital use of statin was associated with a reduced risk of mortality (RR 0.54, 95% CI 0.50-0.58, p < 0.00001; I(2): 0%, p = 0.87), while pre-admission use of statin was not associated with mortality (RR 1.18, 95% CI 0.79-1.77, p = 0.415; I(2): 68.6%, p = 0.013). The funnel plot for the association between the use of statins and mortality were asymmetrical. CONCLUSION: This meta-analysis showed that in-hospital use of statins was associated with a reduced risk of mortality in patients with COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |COVID-19/*mortality/virology[MESH]
  • |Evaluation Studies as Topic[MESH]
  • |Hospitals[MESH]
  • |Humans[MESH]
  • |Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use[MESH]
  • |Risk[MESH]


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