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10.1007/s12519-021-00419-y

http://scihub22266oqcxt.onion/10.1007/s12519-021-00419-y
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33608839!7895741!33608839
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suck abstract from ncbi


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pmid33608839      World+J+Pediatr 2021 ; 17 (2): 141-151
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  • Multisystem inflammatory syndrome in pediatric COVID-19 patients: a meta-analysis #MMPMID33608839
  • Toraih EA; Hussein MH; Elshazli RM; Kline A; Munshi R; Sultana N; Taghavi S; Killackey M; Duchesne J; Fawzy MS; Kandil E
  • World J Pediatr 2021[Apr]; 17 (2): 141-151 PMID33608839show ga
  • BACKGROUND: We aimed to systematically review the clinical and laboratory features of patients with the multisystem inflammatory syndrome in pediatrics diagnosed during the COVID-19 pandemic. DATA SOURCES: A literature search in Web of Science, PubMed, Scopus, and Science Direct was made up to June 29, 2020. RESULTS: Analysis of 15 articles (318 COVID-19 patients) revealed that although many patients presented with the typical multisystem inflammatory syndrome in pediatrics, Kawasaki-like features as fever (82.4%), polymorphous maculopapular exanthema (63.7%), oral mucosal changes (58.1%), conjunctival injections (56.0%), edematous extremities (40.7%), and cervical lymphadenopathy (28.5%), atypical gastrointestinal (79.4%) and neurocognitive symptoms (31.8%) were also common. They had elevated serum lactic acid dehydrogenase, D-dimer, C-reactive protein, procalcitonin, interleukin-6, troponin I levels, and lymphopenia. Nearly 77.0% developed hypotension, and 68.1% went into shock, while 41.1% had acute kidney injury. Intensive care was needed in 73.7% of cases; 13.2% were intubated, and 37.9% required mechanical ventilation. Intravenous immunoglobulins and steroids were given in 87.7% and 56.9% of the patients, respectively, and anticoagulants were utilized in 67.0%. Pediatric patients were discharged after a hospital stay of 6.77 days on average (95% CI 4.93-8.6). CONCLUSIONS: Recognizing the typical and atypical presentation of the multisystem inflammatory syndrome in pediatric COVID-19 patients has important implications in identifying children at risk. Monitoring cardiac and renal decompensation and early interventions in patients with multisystem inflammatory syndrome is critical to prevent further morbidity.
  • |Biomarkers/blood[MESH]
  • |COVID-19/*diagnosis/*therapy[MESH]
  • |Child[MESH]
  • |Critical Care[MESH]
  • |Diagnosis, Differential[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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