COVID-19-from mucosal immunology to IBD patients #MMPMID33608656
Weidinger C; Hegazy AN; Glauben R; Siegmund B
Mucosal Immunol 2021[May]; 14 (3): 566-573 PMID33608656show ga
Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.