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10.1038/s41467-021-20973-3 http://scihub22266oqcxt.onion/10.1038/s41467-021-20973-3 33608538!7896075!33608538     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1152 Nephropedia Template TP {{tp|p=33608538|t=2021. Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity |pdf=|usr=}}{{33608538}} gab.com Text Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33608538 #FOAvip The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis is required to understand the manifestation and progression of COVID-19, monitor seroconversion within the general population, and support vaccine development. The majority of currently available commercial serological assays only quantify the SARS-CoV-2 antibody response against individual antigens, limiting our understanding of the immune response. To overcome this, we have developed a multiplex immunoassay (MultiCoV-Ab) including spike and nucleocapsid proteins of SARS-CoV-2 and the endemic human coronaviruses. Compared to three broadly used commercial in vitro diagnostic tests, our MultiCoV-Ab achieves a higher sensitivity and specificity when analyzing a well-characterized sample set of SARS-CoV-2 infected and uninfected individuals. We find a high response against endemic coronaviruses in our sample set, but no consistent cross-reactive IgG response patterns against SARS-CoV-2. Here we show a robust, high-content-enabled, antigen-saving multiplex assay suited to both monitoring vaccination studies and facilitating epidemiologic screenings for humoral immunity towards pandemic and endemic coronaviruses. Twit Text FOAVip Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33608538 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33608538 #FOAvip English Wikipedia <ref>{{Cite pmid|33608538}}</ref> Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity #MMPMID33608538 Becker M; Strengert M; Junker D; Kaiser PD; Kerrinnes T; Traenkle B; Dinter H; Haring J; Ghozzi S; Zeck A; Weise F; Peter A; Horber S; Fink S; Ruoff F; Dulovic A; Bakchoul T; Baillot A; Lohse S; Cornberg M; Illig T; Gottlieb J; Smola S; Karch A; Berger K; Rammensee HG; Schenke-Layland K; Nelde A; Marklin M; Heitmann JS; Walz JS; Templin M; Joos TO; Rothbauer U; Krause G; Schneiderhan-Marra N Nat Commun 2021[Feb]; 12 (1): 1152 PMID33608538show ga The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis is required to understand the manifestation and progression of COVID-19, monitor seroconversion within the general population, and support vaccine development. The majority of currently available commercial serological assays only quantify the SARS-CoV-2 antibody response against individual antigens, limiting our understanding of the immune response. To overcome this, we have developed a multiplex immunoassay (MultiCoV-Ab) including spike and nucleocapsid proteins of SARS-CoV-2 and the endemic human coronaviruses. Compared to three broadly used commercial in vitro diagnostic tests, our MultiCoV-Ab achieves a higher sensitivity and specificity when analyzing a well-characterized sample set of SARS-CoV-2 infected and uninfected individuals. We find a high response against endemic coronaviruses in our sample set, but no consistent cross-reactive IgG response patterns against SARS-CoV-2. Here we show a robust, high-content-enabled, antigen-saving multiplex assay suited to both monitoring vaccination studies and facilitating epidemiologic screenings for humoral immunity towards pandemic and endemic coronaviruses. |*Cross Reactions[MESH] |*Immunity, Humoral[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19 Serological Testing/*methods[MESH] |COVID-19/diagnosis/*immunology[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Humans[MESH] |Immunoassay[MESH] |Immunoglobulin G/immunology[MESH] |Phosphoproteins/immunology[MESH] |SARS-CoV-2/immunology[MESH] |Sensitivity and Specificity[MESH]Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-A(epmc).pdf DeepDyve Pubget Overpricing