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10.1016/j.bj.2020.11.005

http://scihub22266oqcxt.onion/10.1016/j.bj.2020.11.005
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33608241!7654234!33608241
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suck abstract from ncbi


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pmid33608241      Biomed+J 2021 ; 44 (1): 43-53
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  • Lopinavir/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment #MMPMID33608241
  • Magro P; Zanella I; Pescarolo M; Castelli F; Quiros-Roldan E
  • Biomed J 2021[Mar]; 44 (1): 43-53 PMID33608241show ga
  • Currently, there is no specific antiviral treatment for COVID-19. However, drugs previously developed to treat other viral infections are being tested to verify if they might also be effective against SARS-CoV-2, the virus that causes COVID-19. Twenty years ago, the F.D.A. approved Lopinavir/ritonavir (LPV/r) to treat HIV infection. LPV and ritonavir were initially purposed to inhibit 3-chymotrypsin-like protease (3CL(pro)) of SARS-CoV and MERS-CoV and preliminary promising data on its efficacy for treating people infected with those viruses were available. Therefore, due to the high genetic similarities among those viruses and SARS-CoV-2, early during COVID-19 pandemic LPV/r was also proposed as one emergency treatment. We reviewed data from the literature about LPV/r treatment and SARS-CoV-2 infection, mainly focused on the efficacy and safety of this drugs for COVID-19 treatment. We can conclude that although up to date no clear benefit has been observed with the LPV/r treatment beyond standard care, its efficacy against SARS-COV-2 infection deserves further evaluations, particularly during the very early phase of the disease.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Drug Repositioning[MESH]
  • |*SARS-CoV-2[MESH]
  • |Animals[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Drug Combinations[MESH]
  • |HIV Infections/*drug therapy[MESH]
  • |Humans[MESH]
  • |Lopinavir/*administration & dosage[MESH]


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