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10.1016/j.arr.2021.101299 http://scihub22266oqcxt.onion/10.1016/j.arr.2021.101299 33607290!7885677!33607290     free     free     free       Ageing+Res+Rev 2021 ; 67 (ä): 101299 Nephropedia Template TP {{tp|p=33607290|t=2021. SARS CoV2 infection _The longevity study perspectives |pdf=|usr=}}{{33607290}} gab.com Text SARS CoV2 infection _The longevity study perspectives JO: Ageing Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=33607290 #FOAvip Like other infectious diseases, COVID-19 shows a clinical outcome enormously variable, ranging from asymptomatic to lethal. In Italy, like in other countries, old male individuals, with one or more comorbidity, are the most susceptible group, and show, consequently, the highest mortality, and morbidity, including lethal respiratory distress syndrome, as the most common complication. In addition, another extraordinary peculiarity, that is a surprising resistance to COVID-19, characterizes some Italian nonagenarians/centenarians. Despite having the typical COVID-19 signs and/or symptoms, such exceptional individuals show a surprising tendency to recover from illness and complications. On the other hand, long-lived people have an optimal performance of immune system related to an overexpression of anti-inflammatory variants in immune/inflammatory genes, as demonstrated by our and other groups. Consequently, we suggest long-lived people as an optimal model for detecting genetic profiles associated with the susceptibility and/or protection to COVID-19, to utilize as potential pharmacological targets for preventing or reducing viral infection in more vulnerable individuals. Twit Text FOAVip SARS CoV2 infection _The longevity study perspectives ????Ageing Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=33607290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33607290 #FOAvip English Wikipedia <ref>{{Cite pmid|33607290}}</ref> SARS CoV2 infection _The longevity study perspectives #MMPMID33607290 Lio D; Scola L; Giarratana RM; Candore G; Colonna-Romano G; Caruso C; Balistreri CR Ageing Res Rev 2021[May]; 67 (ä): 101299 PMID33607290show ga Like other infectious diseases, COVID-19 shows a clinical outcome enormously variable, ranging from asymptomatic to lethal. In Italy, like in other countries, old male individuals, with one or more comorbidity, are the most susceptible group, and show, consequently, the highest mortality, and morbidity, including lethal respiratory distress syndrome, as the most common complication. In addition, another extraordinary peculiarity, that is a surprising resistance to COVID-19, characterizes some Italian nonagenarians/centenarians. Despite having the typical COVID-19 signs and/or symptoms, such exceptional individuals show a surprising tendency to recover from illness and complications. On the other hand, long-lived people have an optimal performance of immune system related to an overexpression of anti-inflammatory variants in immune/inflammatory genes, as demonstrated by our and other groups. Consequently, we suggest long-lived people as an optimal model for detecting genetic profiles associated with the susceptibility and/or protection to COVID-19, to utilize as potential pharmacological targets for preventing or reducing viral infection in more vulnerable individuals. |*COVID-19[MESH] |*Severe Acute Respiratory Syndrome/epidemiology[MESH] |Aged, 80 and over[MESH] |Humans[MESH] |Immune System[MESH] |Longevity[MESH] |Male[MESH]SARS CoV2 infection _The longevity study perspectives (epmc).pdf DeepDyve Pubget Overpricing