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10.1002/anie.202016768 http://scihub22266oqcxt.onion/10.1002/anie.202016768 33606889!8014511!33606889     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2021 ; 60 (19): 10716-10723 Nephropedia Template TP {{tp|p=33606889|t=2021. Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease |pdf=|usr=}}{{33606889}} gab.com Text Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33606889 #FOAvip Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CL(pro) ), which is also known as the main protease, is considered among the most important pharmacological targets. The vast majority of investigated 3CL(pro) inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. Re(I) tricarbonyl complexes were identified that demonstrate coordinate covalent enzymatic inhibition of 3CL(pro) . Preliminary studies indicate the selective inhibition of 3CL(pro) over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CL(pro) cysteine protease. Twit Text FOAVip Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33606889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33606889 #FOAvip English Wikipedia <ref>{{Cite pmid|33606889}}</ref> Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease #MMPMID33606889 Karges J; Kalaj M; Gembicky M; Cohen SM Angew Chem Int Ed Engl 2021[May]; 60 (19): 10716-10723 PMID33606889show ga Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CL(pro) ), which is also known as the main protease, is considered among the most important pharmacological targets. The vast majority of investigated 3CL(pro) inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. Re(I) tricarbonyl complexes were identified that demonstrate coordinate covalent enzymatic inhibition of 3CL(pro) . Preliminary studies indicate the selective inhibition of 3CL(pro) over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CL(pro) cysteine protease. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/chemistry/pharmacology[MESH] |Coordination Complexes/chemistry/*pharmacology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors/metabolism[MESH] |Drug Discovery[MESH] |Humans[MESH] |Models, Molecular[MESH] |Protease Inhibitors/chemistry/*pharmacology[MESH] |Rhenium/chemistry/*pharmacology[MESH]Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the (epmc).pdf DeepDyve Pubget Overpricing