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10.1007/s11010-021-04093-6

http://scihub22266oqcxt.onion/10.1007/s11010-021-04093-6
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suck abstract from ncbi


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pmid33604809      Mol+Cell+Biochem 2021 ; 476 (6): 2421-2427
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  • Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives #MMPMID33604809
  • Sengupta T; Majumder R; Majumder S
  • Mol Cell Biochem 2021[Jun]; 476 (6): 2421-2427 PMID33604809show ga
  • Aggressive inflammatory response leading to hypercoagulability has been found to be associated with disease severity in COVID-19 patients and portends bad treatment outcome. A state of acute disseminated intravascular coagulation (DIC), along with pulmonary embolism and/or deep vein thrombosis, has been observed in critically ill ICU patients. Autopsy reports of COVID-19 patients demonstrated microthrombi in lungs and in other organs, as well as marked inflammatory changes, characteristic clinicopathological features that exacerbate disease severity. Vitamin D supplementation was recommended by many clinicians across the globe to improve clinical symptoms of COVID-19 patients, mainly because of its immunomodulatory roles on immune cells. Furthermore, vitamin D and its associated molecules are also known to directly or indirectly regulate various thrombotic pathways. We propose that vitamin D supplementation not only attenuates the risk of Acute Respiratory Disease Syndrome (ARDS) but it also may have a role in reducing coagulation abnormalities in critically ill COVID-19 patients. The overarching goal of this review is to discuss the effects of vitamin D on coagulation pathways and other intertwined processes leading to thrombosis. Many clinical trials are currently investigating the efficacy of vitamin D supplementation in reducing the risk of COVID-19 infection. However, randomized placebo control clinical trials are also necessary to ascertain the effect of vitamin D supplementation on reducing the risk of coagulopathy in COVID-19 patients.
  • |*COVID-19 Drug Treatment[MESH]
  • |Blood Coagulation Disorders/virology[MESH]
  • |COVID-19/complications/*etiology[MESH]
  • |Humans[MESH]
  • |Urachal Cyst/etiology[MESH]
  • |Vitamin D Deficiency/virology[MESH]


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