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10.1007/s00439-021-02264-5 http://scihub22266oqcxt.onion/10.1007/s00439-021-02264-5 33604698!7892327!33604698     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Genet 2021 ; 140 (6): 969-979 Nephropedia Template TP {{tp|p=33604698|t=2021. Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 |pdf=|usr=}}{{33604698}} gab.com Text Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 JO: Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=33604698 #FOAvip SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) and the current health crisis. Despite intensive research efforts, the genes and pathways that contribute to COVID-19 remain poorly understood. We, therefore, used an integrative genomics (IG) approach to identify candidate genes responsible for COVID-19 and its severity. We used Bayesian colocalization (COLOC) and summary-based Mendelian randomization to combine gene expression quantitative trait loci (eQTLs) from the Lung eQTL (n = 1,038) and eQTLGen (n = 31,784) studies with published COVID-19 genome-wide association study (GWAS) data from the COVID-19 Host Genetics Initiative. Additionally, we used COLOC to integrate plasma protein quantitative trait loci (pQTL) from the INTERVAL study (n = 3,301) with COVID-19 loci. Finally, we determined any causal associations between plasma proteins and COVID-19 using multi-variable two-sample Mendelian randomization (MR). The expression of 18 genes in lung and/or blood co-localized with COVID-19 loci. Of these, 12 genes were in suggestive loci (P(GWAS) < 5 x 10(-05)). LZTFL1, SLC6A20, ABO, IL10RB and IFNAR2 and OAS1 had been previously associated with a heightened risk of COVID-19 (P(GWAS) < 5 x 10(-08)). We identified a causal association between OAS1 and COVID-19 GWAS. Plasma ABO protein, which is associated with blood type in humans, demonstrated a significant causal relationship with COVID-19 in the MR analysis; increased plasma levels were associated with an increased risk of COVID-19 and, in particular, severe COVID-19. In summary, our study identified genes associated with COVID-19 that may be prioritized for future investigations. Importantly, this is the first study to demonstrate a causal association between plasma ABO protein and COVID-19. Twit Text FOAVip Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 ????Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=33604698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33604698 #FOAvip English Wikipedia <ref>{{Cite pmid|33604698}}</ref> Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 #MMPMID33604698 Hernandez Cordero AI; Li X; Milne S; Yang CX; Bosse Y; Joubert P; Timens W; van den Berge M; Nickle D; Hao K; Sin DD Hum Genet 2021[Jun]; 140 (6): 969-979 PMID33604698show ga SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) and the current health crisis. Despite intensive research efforts, the genes and pathways that contribute to COVID-19 remain poorly understood. We, therefore, used an integrative genomics (IG) approach to identify candidate genes responsible for COVID-19 and its severity. We used Bayesian colocalization (COLOC) and summary-based Mendelian randomization to combine gene expression quantitative trait loci (eQTLs) from the Lung eQTL (n = 1,038) and eQTLGen (n = 31,784) studies with published COVID-19 genome-wide association study (GWAS) data from the COVID-19 Host Genetics Initiative. Additionally, we used COLOC to integrate plasma protein quantitative trait loci (pQTL) from the INTERVAL study (n = 3,301) with COVID-19 loci. Finally, we determined any causal associations between plasma proteins and COVID-19 using multi-variable two-sample Mendelian randomization (MR). The expression of 18 genes in lung and/or blood co-localized with COVID-19 loci. Of these, 12 genes were in suggestive loci (P(GWAS) < 5 x 10(-05)). LZTFL1, SLC6A20, ABO, IL10RB and IFNAR2 and OAS1 had been previously associated with a heightened risk of COVID-19 (P(GWAS) < 5 x 10(-08)). We identified a causal association between OAS1 and COVID-19 GWAS. Plasma ABO protein, which is associated with blood type in humans, demonstrated a significant causal relationship with COVID-19 in the MR analysis; increased plasma levels were associated with an increased risk of COVID-19 and, in particular, severe COVID-19. In summary, our study identified genes associated with COVID-19 that may be prioritized for future investigations. Importantly, this is the first study to demonstrate a causal association between plasma ABO protein and COVID-19. |*Genetic Predisposition to Disease[MESH] |*Polymorphism, Single Nucleotide[MESH] |*Quantitative Trait Loci[MESH] |ABO Blood-Group System/metabolism[MESH] |Blood Proteins/*metabolism[MESH] |COVID-19/*epidemiology/metabolism/virology[MESH] |Cohort Studies[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Lung/*metabolism[MESH] |Mendelian Randomization Analysis[MESH] |Risk Factors[MESH]Multi-omics highlights ABO plasma protein as a causal risk factor for (epmc).pdf DeepDyve Pubget Overpricing