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10.3389/fimmu.2020.624411 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.624411 33603755!7884312!33603755     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 624411 Nephropedia Template TP {{tp|p=33603755|t=2020. Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases |pdf=|usr=}}{{33603755}} gab.com Text Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33603755 #FOAvip SARS-CoV-2 is wreaking havoc around the world. To get the world back on track, hundreds of vaccines are under development. A deeper understanding of how the immune system responds to SARS-CoV-2 re-infection will certainly help. Studies have highlighted various aspects of T cell response in resolving acute infection and preventing re-infections. Lung resident memory T (T(RM)) cells are sentinels in the secondary immune response. They are mostly differentiated from effector T cells, construct specific niches and stay permanently in lung tissues. If the infection recurs, locally activated lung T(RM) cells can elicit rapid immune response against invading pathogens. In addition, they can significantly limit tumor growth or lead to pathologic immune responses. Vaccines targeting T(RM) cells are under development, with the hope to induce stable and highly reactive lung T(RM) cells through mucosal administration or "prime-and-pull" strategy. In this review, we will summarize recent advances in lung T(RM) cell generation and maintenance, explore their roles in different diseases and discuss how these cells may guide the development of future vaccines targeting infectious disease, cancer, and pathologic immune response. Twit Text FOAVip Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33603755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33603755 #FOAvip English Wikipedia <ref>{{Cite pmid|33603755}}</ref> Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases #MMPMID33603755 Qian Y; Zhu Y; Li Y; Li B Front Immunol 2020[]; 11 (ä): 624411 PMID33603755show ga SARS-CoV-2 is wreaking havoc around the world. To get the world back on track, hundreds of vaccines are under development. A deeper understanding of how the immune system responds to SARS-CoV-2 re-infection will certainly help. Studies have highlighted various aspects of T cell response in resolving acute infection and preventing re-infections. Lung resident memory T (T(RM)) cells are sentinels in the secondary immune response. They are mostly differentiated from effector T cells, construct specific niches and stay permanently in lung tissues. If the infection recurs, locally activated lung T(RM) cells can elicit rapid immune response against invading pathogens. In addition, they can significantly limit tumor growth or lead to pathologic immune responses. Vaccines targeting T(RM) cells are under development, with the hope to induce stable and highly reactive lung T(RM) cells through mucosal administration or "prime-and-pull" strategy. In this review, we will summarize recent advances in lung T(RM) cell generation and maintenance, explore their roles in different diseases and discuss how these cells may guide the development of future vaccines targeting infectious disease, cancer, and pathologic immune response. |Animals[MESH] |COVID-19/*immunology[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Immunotherapy, Adoptive/*methods[MESH] |Lung/*immunology[MESH] |Lymphocyte Activation[MESH] |Neoplasms/*immunology[MESH] |SARS-CoV-2/*physiology[MESH] |T-Lymphocytes/*immunology/transplantation[MESH]Legend of the Sentinels: Development of Lung Resident Memory T Cells a(epmc).pdf DeepDyve Pubget Overpricing