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10.1038/s41422-021-00473-1 http://scihub22266oqcxt.onion/10.1038/s41422-021-00473-1 33603116!7890106!33603116     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2021 ; 31 (4): 395-403 Nephropedia Template TP {{tp|p=33603116|t=2021. Coinfection with influenza A virus enhances SARS-CoV-2 infectivity |pdf=|usr=}}{{33603116}} gab.com Text Coinfection with influenza A virus enhances SARS-CoV-2 infectivity JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=33603116 #FOAvip The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic. Twit Text FOAVip Coinfection with influenza A virus enhances SARS-CoV-2 infectivity ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=33603116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33603116 #FOAvip English Wikipedia <ref>{{Cite pmid|33603116}}</ref> Coinfection with influenza A virus enhances SARS-CoV-2 infectivity #MMPMID33603116 Bai L; Zhao Y; Dong J; Liang S; Guo M; Liu X; Wang X; Huang Z; Sun X; Zhang Z; Dong L; Liu Q; Zheng Y; Niu D; Xiang M; Song K; Ye J; Zheng W; Tang Z; Tang M; Zhou Y; Shen C; Dai M; Zhou L; Chen Y; Yan H; Lan K; Xu K Cell Res 2021[Apr]; 31 (4): 395-403 PMID33603116show ga The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic. |Angiotensin-Converting Enzyme 2/deficiency/genetics/metabolism[MESH] |Animals[MESH] |COVID-19/*pathology/virology[MESH] |Cathepsin L/genetics/metabolism[MESH] |Cell Line[MESH] |Coinfection/*pathology/virology[MESH] |Humans[MESH] |Influenza A virus/isolation & purification/*physiology[MESH] |Lung/pathology[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Orthomyxoviridae Infections/*pathology/virology[MESH] |SARS-CoV-2/isolation & purification/*physiology[MESH] |Serine Endopeptidases/genetics/metabolism[MESH] |Severity of Illness Index[MESH] |Viral Load[MESH]Coinfection with influenza A virus enhances SARS-CoV-2 infectivity (epmc).pdf DeepDyve Pubget Overpricing