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10.1101/gr.268961.120 http://scihub22266oqcxt.onion/10.1101/gr.268961.120 33602693!8015855!33602693     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Res 2021 ; 31 (4): 635-644 Nephropedia Template TP {{tp|p=33602693|t=2021. SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission |pdf=|usr=}}{{33602693}} gab.com Text SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=33602693 #FOAvip The COVID-19 pandemic has sparked an urgent need to uncover the underlying biology of this devastating disease. Though RNA viruses mutate more rapidly than DNA viruses, there are a relatively small number of single nucleotide polymorphisms (SNPs) that differentiate the main SARS-CoV-2 lineages that have spread throughout the world. In this study, we investigated 129 RNA-seq data sets and 6928 consensus genomes to contrast the intra-host and inter-host diversity of SARS-CoV-2. Our analyses yielded three major observations. First, the mutational profile of SARS-CoV-2 highlights intra-host single nucleotide variant (iSNV) and SNP similarity, albeit with differences in C > U changes. Second, iSNV and SNP patterns in SARS-CoV-2 are more similar to MERS-CoV than SARS-CoV-1. Third, a significant fraction of insertions and deletions contribute to the genetic diversity of SARS-CoV-2. Altogether, our findings provide insight into SARS-CoV-2 genomic diversity, inform the design of detection tests, and highlight the potential of iSNVs for tracking the transmission of SARS-CoV-2. Twit Text FOAVip SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=33602693 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33602693 #FOAvip English Wikipedia <ref>{{Cite pmid|33602693}}</ref> SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission #MMPMID33602693 Sapoval N; Mahmoud M; Jochum MD; Liu Y; Elworth RAL; Wang Q; Albin D; Ogilvie HA; Lee MD; Villapol S; Hernandez KM; Maljkovic Berry I; Foox J; Beheshti A; Ternus K; Aagaard KM; Posada D; Mason CE; Sedlazeck FJ; Treangen TJ Genome Res 2021[Apr]; 31 (4): 635-644 PMID33602693show ga The COVID-19 pandemic has sparked an urgent need to uncover the underlying biology of this devastating disease. Though RNA viruses mutate more rapidly than DNA viruses, there are a relatively small number of single nucleotide polymorphisms (SNPs) that differentiate the main SARS-CoV-2 lineages that have spread throughout the world. In this study, we investigated 129 RNA-seq data sets and 6928 consensus genomes to contrast the intra-host and inter-host diversity of SARS-CoV-2. Our analyses yielded three major observations. First, the mutational profile of SARS-CoV-2 highlights intra-host single nucleotide variant (iSNV) and SNP similarity, albeit with differences in C > U changes. Second, iSNV and SNP patterns in SARS-CoV-2 are more similar to MERS-CoV than SARS-CoV-1. Third, a significant fraction of insertions and deletions contribute to the genetic diversity of SARS-CoV-2. Altogether, our findings provide insight into SARS-CoV-2 genomic diversity, inform the design of detection tests, and highlight the potential of iSNVs for tracking the transmission of SARS-CoV-2. |*Genetic Variation[MESH] |*Genome, Viral[MESH] |COVID-19/*diagnosis/*transmission/virology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Polymorphism, Single Nucleotide[MESH] |Real-Time Polymerase Chain Reaction/*methods[MESH]SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnost(epmc).pdf DeepDyve Pubget Overpricing