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10.1177/0284185121994695

http://scihub22266oqcxt.onion/10.1177/0284185121994695
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33601893!ä!33601893

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suck abstract from ncbi


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pmid33601893      Acta+Radiol 2022 ; 63 (3): 319-327
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  • Radiomics analysis enables fatal outcome prediction for hospitalized patients with coronavirus disease 2019 (COVID-19) #MMPMID33601893
  • Ke Z; Li L; Wang L; Liu H; Lu X; Zeng F; Zha Y
  • Acta Radiol 2022[Mar]; 63 (3): 319-327 PMID33601893show ga
  • BACKGROUND: In December 2019, a rare respiratory disease named coronavirus disease 2019 (COVID-19) broke out, leading to great concern around the world. PURPOSE: To develop and validate a radiomics nomogram for predicting the fatal outcome of COVID-19 pneumonia. MATERIAL AND METHODS: The present study consisted of a training dataset (n = 66) and a validation dataset (n = 30) with COVID-19 from January 2020 to March 2020. A radiomics signature was generated using the least absolute shrinkage and selection operator (LASSO) Cox regression model. A radiomics score (Rad-score) was developed from the training cohort. The radiomics model, clinical model, and integrated model were built to assess the association between radiomics signature/clinical characteristics and the mortality of COVID-19 cases. The radiomics signature combined with the Rad-score and the independent clinical factors and radiomics nomogram were constructed. RESULTS: Seven stable radiomics features associated with the mortality of COVID-19 were finally selected. A radiomics nomogram was based on a combined model consisting of the radiomics signature and the clinical risk factors indicating optimal predictive performance for the fatal outcome of patients with COVID-19 with a C-index of 0.912 (95% confidence interval [CI] 0.867-0.957) in the training dataset and 0.907 (95% CI 0.849-0.966) in the validation dataset. The calibration curves indicated optimal consistency between the prediction and the observation in both training and validation cohorts. CONCLUSION: The CT-based radiomics nomogram indicated favorable predictive efficacy for the overall survival risk of patients with COVID-19, which could help clinicians intensively follow up high-risk patients and make timely diagnoses.
  • |*Inpatients[MESH]
  • |*Nomograms[MESH]
  • |*Tomography, X-Ray Computed[MESH]
  • |COVID-19/*diagnostic imaging/*mortality[MESH]
  • |Confidence Intervals[MESH]
  • |Datasets as Topic[MESH]
  • |Humans[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]


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