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10.1016/j.amjms.2021.02.012 http://scihub22266oqcxt.onion/10.1016/j.amjms.2021.02.012 33600784!7884223!33600784     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Med+Sci 2021 ; 361 (5): 585-590 Nephropedia Template TP {{tp|p=33600784|t=2021. DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19 |pdf=|usr=}}{{33600784}} gab.com Text DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19 JO: Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33600784 #FOAvip BACKGROUND: Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) oxidative damage is associated with mortality of patients with different diseases. However, there are no data about DNA and RNA oxidative damage from coronavirus disease 2019 (COVID-19) patients. Thus, the objective of this study was to explore DNA and RNA oxidative damage in surviving and non-surviving COVID-19 patients. MATERIALS AND METHODS: Eight Intensive Care Units from 6 hospitals in the Canary Islands (Spain) participated in this prospective and observational study. We recorded the serum levels at ICU admission of the three guanine oxidized species (OGS) because guanine is the nucleobase that forms the DNA and RNA most prone to oxidation. Survival at 30 days was our end-point study. RESULTS: Non-surviving (n = 11) compared to surviving patients (n = 42) had higher APACHE-II (p < 0.001), SOFA (p = 0.004) and serum OGS levels (p = 0.001). In logistic regression analyses an association between serum OGS levels and 30-day mortality after controlling for SOFA (OR=2.601; 95% CI=1.305-5.182; p = 0.007) or APACHE-II (OR=2.493; 95% CI=1.274-4.879; p = 0.008) was found. The area under curve (AUC) for mortality prediction by serum OGS levels was 83% (95% CI=70-92%; p < 0.001), by APACHE II was 85% (95% CI=75-96%; p < 0.001), and by SOFA was 80% (95% CI=66-94%; p < 0.001). No significant differences were found in the AUC between serum OGS levels and SOFA (p = 0.91), and serum OGS levels and APACHE-II (p = 0.64). CONCLUSIONS: To our knowledge, this is the first study reporting on oxidative DNA and RNA damage in COVID-19 patients, and the main new finding was that serum OGS concentration was associated with mortality. Twit Text FOAVip DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19 ????Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33600784 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33600784 #FOAvip English Wikipedia <ref>{{Cite pmid|33600784}}</ref> DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19 #MMPMID33600784 Lorente L; Martin MM; Gonzalez-Rivero AF; Perez-Cejas A; Caceres JJ; Perez A; Ramos-Gomez L; Sole-Violan J; Marcos Y Ramos JA; Ojeda N; Jimenez A Am J Med Sci 2021[May]; 361 (5): 585-590 PMID33600784show ga BACKGROUND: Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) oxidative damage is associated with mortality of patients with different diseases. However, there are no data about DNA and RNA oxidative damage from coronavirus disease 2019 (COVID-19) patients. Thus, the objective of this study was to explore DNA and RNA oxidative damage in surviving and non-surviving COVID-19 patients. MATERIALS AND METHODS: Eight Intensive Care Units from 6 hospitals in the Canary Islands (Spain) participated in this prospective and observational study. We recorded the serum levels at ICU admission of the three guanine oxidized species (OGS) because guanine is the nucleobase that forms the DNA and RNA most prone to oxidation. Survival at 30 days was our end-point study. RESULTS: Non-surviving (n = 11) compared to surviving patients (n = 42) had higher APACHE-II (p < 0.001), SOFA (p = 0.004) and serum OGS levels (p = 0.001). In logistic regression analyses an association between serum OGS levels and 30-day mortality after controlling for SOFA (OR=2.601; 95% CI=1.305-5.182; p = 0.007) or APACHE-II (OR=2.493; 95% CI=1.274-4.879; p = 0.008) was found. The area under curve (AUC) for mortality prediction by serum OGS levels was 83% (95% CI=70-92%; p < 0.001), by APACHE II was 85% (95% CI=75-96%; p < 0.001), and by SOFA was 80% (95% CI=66-94%; p < 0.001). No significant differences were found in the AUC between serum OGS levels and SOFA (p = 0.91), and serum OGS levels and APACHE-II (p = 0.64). CONCLUSIONS: To our knowledge, this is the first study reporting on oxidative DNA and RNA damage in COVID-19 patients, and the main new finding was that serum OGS concentration was associated with mortality. |*COVID-19/metabolism/mortality[MESH] |*DNA Damage[MESH] |Aged[MESH] |DNA/*metabolism[MESH] |Disease-Free Survival[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Oxidation-Reduction[MESH] |RNA/*metabolism[MESH] |SARS-CoV-2/*metabolism[MESH] |Spain/epidemiology[MESH]DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19 (epmc).pdf DeepDyve Pubget Overpricing