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10.1172/jci.insight.141690 http://scihub22266oqcxt.onion/10.1172/jci.insight.141690 33600379!8026188!33600379     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (6): ä Nephropedia Template TP {{tp|p=33600379|t=2021. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia |pdf=|usr=}}{{33600379}} gab.com Text Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33600379 #FOAvip Regulatory T (Treg) cells orchestrate resolution and repair of acute lung inflammation and injury after viral pneumonia. Compared with younger patients, older individuals experience impaired recovery and worse clinical outcomes after severe viral infections, including influenza and SARS coronavirus 2 (SARS-CoV-2). Whether age is a key determinant of Treg cell prorepair function after lung injury remains unknown. Here, we showed that aging results in a cell-autonomous impairment of reparative Treg cell function after experimental influenza pneumonia. Transcriptional and DNA methylation profiling of sorted Treg cells provided insight into the mechanisms underlying their age-related dysfunction, with Treg cells from aged mice demonstrating both loss of reparative programs and gain of maladaptive programs. Strategies to restore youthful Treg cell functional programs could be leveraged as therapies to improve outcomes among older individuals with severe viral pneumonia. Twit Text FOAVip Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33600379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33600379 #FOAvip English Wikipedia <ref>{{Cite pmid|33600379}}</ref> Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia #MMPMID33600379 Morales-Nebreda L; Helmin KA; Torres Acosta MA; Markov NS; Hu JY; Joudi AM; Piseaux-Aillon R; Abdala-Valencia H; Politanska Y; Singer BD JCI Insight 2021[Mar]; 6 (6): ä PMID33600379show ga Regulatory T (Treg) cells orchestrate resolution and repair of acute lung inflammation and injury after viral pneumonia. Compared with younger patients, older individuals experience impaired recovery and worse clinical outcomes after severe viral infections, including influenza and SARS coronavirus 2 (SARS-CoV-2). Whether age is a key determinant of Treg cell prorepair function after lung injury remains unknown. Here, we showed that aging results in a cell-autonomous impairment of reparative Treg cell function after experimental influenza pneumonia. Transcriptional and DNA methylation profiling of sorted Treg cells provided insight into the mechanisms underlying their age-related dysfunction, with Treg cells from aged mice demonstrating both loss of reparative programs and gain of maladaptive programs. Strategies to restore youthful Treg cell functional programs could be leveraged as therapies to improve outcomes among older individuals with severe viral pneumonia. |*Influenza A virus[MESH] |*SARS-CoV-2[MESH] |Age Factors[MESH] |Aging/metabolism/*physiology[MESH] |Animals[MESH] |COVID-19/complications/metabolism/pathology/virology[MESH] |Humans[MESH] |Influenza, Human/complications/metabolism/*pathology/virology[MESH] |Lung/metabolism/*pathology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Pneumonia, Viral/etiology/metabolism/*pathology/virology[MESH]Aging imparts cell-autonomous dysfunction to regulatory T cells during(epmc).pdf DeepDyve Pubget Overpricing