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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Med+Internet+Res 2021 ; 23 (3): e22219 Nephropedia Template TP
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What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask #MMPMID33600347
Kohane IS; Aronow BJ; Avillach P; Beaulieu-Jones BK; Bellazzi R; Bradford RL; Brat GA; Cannataro M; Cimino JJ; Garcia-Barrio N; Gehlenborg N; Ghassemi M; Gutierrez-Sacristan A; Hanauer DA; Holmes JH; Hong C; Klann JG; Loh NHW; Luo Y; Mandl KD; Daniar M; Moore JH; Murphy SN; Neuraz A; Ngiam KY; Omenn GS; Palmer N; Patel LP; Pedrera-Jimenez M; Sliz P; South AM; Tan ALM; Taylor DM; Taylor BW; Torti C; Vallejos AK; Wagholikar KB; Weber GM; Cai T
J Med Internet Res 2021[Mar]; 23 (3): e22219 PMID33600347show ga
Coincident with the tsunami of COVID-19-related publications, there has been a surge of studies using real-world data, including those obtained from the electronic health record (EHR). Unfortunately, several of these high-profile publications were retracted because of concerns regarding the soundness and quality of the studies and the EHR data they purported to analyze. These retractions highlight that although a small community of EHR informatics experts can readily identify strengths and flaws in EHR-derived studies, many medical editorial teams and otherwise sophisticated medical readers lack the framework to fully critically appraise these studies. In addition, conventional statistical analyses cannot overcome the need for an understanding of the opportunities and limitations of EHR-derived studies. We distill here from the broader informatics literature six key considerations that are crucial for appraising studies utilizing EHR data: data completeness, data collection and handling (eg, transformation), data type (ie, codified, textual), robustness of methods against EHR variability (within and across institutions, countries, and time), transparency of data and analytic code, and the multidisciplinary approach. These considerations will inform researchers, clinicians, and other stakeholders as to the recommended best practices in reviewing manuscripts, grants, and other outputs from EHR-data derived studies, and thereby promote and foster rigor, quality, and reliability of this rapidly growing field.