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10.1080/14760584.2021.1891889 http://scihub22266oqcxt.onion/10.1080/14760584.2021.1891889 33599178!ä!33599178 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33599178&cmd=llinks): Failed to open stream: HTTP request failed! 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Hypothetical emergence of poliovirus in 2020: part 2 exploration of the potential role of vaccines in control and eradication |pdf=|usr=}}{{33599178}} gab.com Text Hypothetical emergence of poliovirus in 2020: part 2 exploration of the potential role of vaccines in control and eradication JO: Expert Rev Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33599178 #FOAvip OBJECTIVES: The emergence of human pathogens with pandemic potential motivates rapid vaccine development. We explore the role of vaccines in control and eradication of a novel emerging pathogen. METHODS: We hypothetically simulate emergence of a novel wild poliovirus (nWPV) in 2020 assuming an immunologically naive population. Assuming different nonpharmaceutical interventions (NPIs), we explore the impacts of vaccines resembling serotype-specific oral poliovirus vaccine (OPV), novel OPV (nOPV), or inactivated poliovirus vaccine (IPV). RESULTS: Vaccines most effectively change the trajectory of an emerging disease when disseminated early, rapidly, and widely in the background of ongoing strict NPIs, unless the NPIs successfully eradicate the emerging pathogen before it establishes endemic transmission. Without strict NPIs, vaccines primarily reduce the burden of disease in the remaining susceptible individuals and in new birth cohorts. Live virus vaccines that effectively compete with the nWPVs can reduce disease burdens more than other vaccines. When relaxation of existing NPIs occurs at the time of vaccine introduction, nWPV transmission can counterintuitively increase in the short term. CONCLUSIONS: Vaccines can increase the probability of disease eradication in the context of strict NPIs. However, successful eradication will depend on specific immunization strategies used and a global commitment to eradication. Twit Text FOAVip Hypothetical emergence of poliovirus in 2020: part 2 exploration of the potential role of vaccines in control and eradication ????Expert Rev Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33599178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33599178 #FOAvip English Wikipedia <ref>{{Cite pmid|33599178}}</ref> Hypothetical emergence of poliovirus in 2020: part 2 exploration of the potential role of vaccines in control and eradication #MMPMID33599178 Thompson KM; Kalkowska DA; Badizadegan K Expert Rev Vaccines 2021[Apr]; 20 (4): 449-460 PMID33599178show ga OBJECTIVES: The emergence of human pathogens with pandemic potential motivates rapid vaccine development. We explore the role of vaccines in control and eradication of a novel emerging pathogen. METHODS: We hypothetically simulate emergence of a novel wild poliovirus (nWPV) in 2020 assuming an immunologically naive population. Assuming different nonpharmaceutical interventions (NPIs), we explore the impacts of vaccines resembling serotype-specific oral poliovirus vaccine (OPV), novel OPV (nOPV), or inactivated poliovirus vaccine (IPV). RESULTS: Vaccines most effectively change the trajectory of an emerging disease when disseminated early, rapidly, and widely in the background of ongoing strict NPIs, unless the NPIs successfully eradicate the emerging pathogen before it establishes endemic transmission. Without strict NPIs, vaccines primarily reduce the burden of disease in the remaining susceptible individuals and in new birth cohorts. Live virus vaccines that effectively compete with the nWPVs can reduce disease burdens more than other vaccines. When relaxation of existing NPIs occurs at the time of vaccine introduction, nWPV transmission can counterintuitively increase in the short term. CONCLUSIONS: Vaccines can increase the probability of disease eradication in the context of strict NPIs. However, successful eradication will depend on specific immunization strategies used and a global commitment to eradication. |Disease Eradication/*methods/trends[MESH] |Disease Outbreaks/prevention & control[MESH] |Global Health/trends[MESH] |Humans[MESH] |Poliomyelitis/*epidemiology/*prevention & control[MESH] |Poliovirus Vaccine, Inactivated/*administration & dosage[MESH] |Poliovirus Vaccine, Oral/*administration & dosage[MESH] |Poliovirus/*drug effects/physiology[MESH]Hypothetical emergence of poliovirus in 2020: part 2 exploration of t(epmc).pdf DeepDyve Pubget Overpricing