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10.3389/fimmu.2021.622738 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.622738 33597956!7882731!33597956     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 622738 Nephropedia Template TP {{tp|p=33597956|t=2021. Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal |pdf=|usr=}}{{33597956}} gab.com Text Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33597956 #FOAvip Pathogenesis of cytokine storm is poorly understood. In this article we propose a new mechanism and suggest innovative therapeutic avenues for its prevention. We have reported that particles of cell-free chromatin (cfCh) that are released from the billions of cells that die in the body everyday can illegitimately integrate into genomes of healthy cells to trigger dsDNA breaks. The latter leads to apoptosis and/or intense activation of inflammatory cytokines in the affected cells. We hypothesise that a similar phenomenon of dsDNA breaks and inflammation is involved in cytokine storm. The abundant cfCh particles that are released from dying host cells following viral/microbial invasion initiate a cascading effect of more cell death resulting in a vicious cycle of further DNA damage, apoptosis and hyper-inflammation which culminate in cytokine storm. We propose that this unrelenting vicious cycle of cellular DNA damage and cytokine storm may be the underlying cause of high mortality from severe COVID-19. We discuss results of our preclinical studies wherein we have shown that endotoxin induced cytokine storm in mice can be reversed by three different agents that have the ability to inactivate cfCh. These agents may be worthy of investigation in clinical trials to reduce mortality from COVID-19. Twit Text FOAVip Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33597956 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33597956 #FOAvip English Wikipedia <ref>{{Cite pmid|33597956}}</ref> Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal #MMPMID33597956 Shabrish S; Mittra I Front Immunol 2021[]; 12 (ä): 622738 PMID33597956show ga Pathogenesis of cytokine storm is poorly understood. In this article we propose a new mechanism and suggest innovative therapeutic avenues for its prevention. We have reported that particles of cell-free chromatin (cfCh) that are released from the billions of cells that die in the body everyday can illegitimately integrate into genomes of healthy cells to trigger dsDNA breaks. The latter leads to apoptosis and/or intense activation of inflammatory cytokines in the affected cells. We hypothesise that a similar phenomenon of dsDNA breaks and inflammation is involved in cytokine storm. The abundant cfCh particles that are released from dying host cells following viral/microbial invasion initiate a cascading effect of more cell death resulting in a vicious cycle of further DNA damage, apoptosis and hyper-inflammation which culminate in cytokine storm. We propose that this unrelenting vicious cycle of cellular DNA damage and cytokine storm may be the underlying cause of high mortality from severe COVID-19. We discuss results of our preclinical studies wherein we have shown that endotoxin induced cytokine storm in mice can be reversed by three different agents that have the ability to inactivate cfCh. These agents may be worthy of investigation in clinical trials to reduce mortality from COVID-19. |Apoptosis[MESH] |COVID-19/*immunology[MESH] |Cell Death[MESH] |Cytokine Release Syndrome/*immunology[MESH] |DNA Breaks, Double-Stranded[MESH] |Endotoxins/metabolism[MESH] |Free Radicals/metabolism[MESH] |Humans[MESH] |Inflammation/*immunology[MESH]Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal (epmc).pdf DeepDyve Pubget Overpricing