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10.1038/s41467-021-21289-y http://scihub22266oqcxt.onion/10.1038/s41467-021-21289-y 33597532!7889643!33597532     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1079 Nephropedia Template TP {{tp|p=33597532|t=2021. Dysregulated transcriptional responses to SARS-CoV-2 in the periphery |pdf=|usr=}}{{33597532}} gab.com Text Dysregulated transcriptional responses to SARS-CoV-2 in the periphery JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33597532 #FOAvip SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of the host response to SARS-CoV-2 infection through RNA sequencing of peripheral blood samples from 46 subjects with COVID-19 and directly comparing them to subjects with seasonal coronavirus, influenza, bacterial pneumonia, and healthy controls. Early SARS-CoV-2 infection triggers a powerful transcriptomic response in peripheral blood with conserved components that are heavily interferon-driven but also marked by indicators of early B-cell activation and antibody production. Interferon responses during SARS-CoV-2 infection demonstrate unique patterns of dysregulated expression compared to other infectious and healthy states. Heterogeneous activation of coagulation and fibrinolytic pathways are present in early COVID-19, as are IL1 and JAK/STAT signaling pathways, which persist into late disease. Classifiers based on differentially expressed genes accurately distinguished SARS-CoV-2 infection from other acute illnesses (auROC 0.95 [95% CI 0.92-0.98]). The transcriptome in peripheral blood reveals both diverse and conserved components of the immune response in COVID-19 and provides for potential biomarker-based approaches to diagnosis. Twit Text FOAVip Dysregulated transcriptional responses to SARS-CoV-2 in the periphery ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33597532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33597532 #FOAvip English Wikipedia <ref>{{Cite pmid|33597532}}</ref> Dysregulated transcriptional responses to SARS-CoV-2 in the periphery #MMPMID33597532 McClain MT; Constantine FJ; Henao R; Liu Y; Tsalik EL; Burke TW; Steinbrink JM; Petzold E; Nicholson BP; Rolfe R; Kraft BD; Kelly MS; Saban DR; Yu C; Shen X; Ko EM; Sempowski GD; Denny TN; Ginsburg GS; Woods CW Nat Commun 2021[Feb]; 12 (1): 1079 PMID33597532show ga SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of the host response to SARS-CoV-2 infection through RNA sequencing of peripheral blood samples from 46 subjects with COVID-19 and directly comparing them to subjects with seasonal coronavirus, influenza, bacterial pneumonia, and healthy controls. Early SARS-CoV-2 infection triggers a powerful transcriptomic response in peripheral blood with conserved components that are heavily interferon-driven but also marked by indicators of early B-cell activation and antibody production. Interferon responses during SARS-CoV-2 infection demonstrate unique patterns of dysregulated expression compared to other infectious and healthy states. Heterogeneous activation of coagulation and fibrinolytic pathways are present in early COVID-19, as are IL1 and JAK/STAT signaling pathways, which persist into late disease. Classifiers based on differentially expressed genes accurately distinguished SARS-CoV-2 infection from other acute illnesses (auROC 0.95 [95% CI 0.92-0.98]). The transcriptome in peripheral blood reveals both diverse and conserved components of the immune response in COVID-19 and provides for potential biomarker-based approaches to diagnosis. |COVID-19/blood/*genetics/virology[MESH] |Cytokines/genetics[MESH] |Gene Expression Profiling/*methods[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Influenza, Human/genetics[MESH] |Leukocytes, Mononuclear/*metabolism[MESH] |Pneumonia, Bacterial/genetics[MESH] |SARS-CoV-2/physiology[MESH] |Sequence Analysis, RNA/*methods[MESH] |Signal Transduction/genetics[MESH]Dysregulated transcriptional responses to SARS-CoV-2 in the periphery (epmc).pdf DeepDyve Pubget Overpricing