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10.1038/s41467-021-21414-x http://scihub22266oqcxt.onion/10.1038/s41467-021-21414-x 33597531!7889848!33597531     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1084 Nephropedia Template TP {{tp|p=33597531|t=2021. Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children |pdf=|usr=}}{{33597531}} gab.com Text Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33597531 #FOAvip Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild SARS-CoV-2 infection in children is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells and natural killer cells during the acute phase. In contrast, SARS-CoV-2-infected adults show reduced proportions of non-classical monocytes only. We also observe increased proportions of CD63+ activated neutrophils during the acute phase to SARS-CoV-2 in infected children. Children and adults exposed to SARS-CoV-2 but negative on PCR testing display increased proportions of low-density neutrophils that we observe up to 7 weeks post exposure. This study characterises the innate immune response during SARS-CoV-2 infection and household exposure in children. Twit Text FOAVip Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33597531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33597531 #FOAvip English Wikipedia <ref>{{Cite pmid|33597531}}</ref> Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children #MMPMID33597531 Neeland MR; Bannister S; Clifford V; Dohle K; Mulholland K; Sutton P; Curtis N; Steer AC; Burgner DP; Crawford NW; Tosif S; Saffery R Nat Commun 2021[Feb]; 12 (1): 1084 PMID33597531show ga Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild SARS-CoV-2 infection in children is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells and natural killer cells during the acute phase. In contrast, SARS-CoV-2-infected adults show reduced proportions of non-classical monocytes only. We also observe increased proportions of CD63+ activated neutrophils during the acute phase to SARS-CoV-2 in infected children. Children and adults exposed to SARS-CoV-2 but negative on PCR testing display increased proportions of low-density neutrophils that we observe up to 7 weeks post exposure. This study characterises the innate immune response during SARS-CoV-2 infection and household exposure in children. |Adolescent[MESH] |Adult[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/blood/*immunology/virology[MESH] |Child[MESH] |Child, Preschool[MESH] |Dendritic Cells/immunology[MESH] |Eosinophils/immunology[MESH] |Humans[MESH] |Immunity, Innate/*immunology[MESH] |Infant[MESH] |Killer Cells, Natural/immunology[MESH] |Leukocytes, Mononuclear/immunology[MESH] |Middle Aged[MESH] |Neutrophils/immunology[MESH] |SARS-CoV-2/genetics/*immunology/physiology[MESH]Innate cell profiles during the acute and convalescent phase of SARS-C(epmc).pdf DeepDyve Pubget Overpricing