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10.1126/science.abf4896 http://scihub22266oqcxt.onion/10.1126/science.abf4896 33597220!8011693!33597220     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33597220&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 371 (6536): 1379-1382 Nephropedia Template TP {{tp|p=33597220|t=2021. Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets |pdf=|usr=}}{{33597220}} gab.com Text Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33597220 #FOAvip Containment of the COVID-19 pandemic requires reducing viral transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion between the viral and host cell membranes, which is mediated by the viral spike protein. We have designed lipopeptide fusion inhibitors that block this critical first step of infection and, on the basis of in vitro efficacy and in vivo biodistribution, selected a dimeric form for evaluation in an animal model. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour cohousing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and thus may readily translate into safe and effective intranasal prophylaxis to reduce transmission of SARS-CoV-2. Twit Text FOAVip Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33597220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33597220 #FOAvip English Wikipedia <ref>{{Cite pmid|33597220}}</ref> Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets #MMPMID33597220 de Vries RD; Schmitz KS; Bovier FT; Predella C; Khao J; Noack D; Haagmans BL; Herfst S; Stearns KN; Drew-Bear J; Biswas S; Rockx B; McGill G; Dorrello NV; Gellman SH; Alabi CA; de Swart RL; Moscona A; Porotto M Science 2021[Mar]; 371 (6536): 1379-1382 PMID33597220show ga Containment of the COVID-19 pandemic requires reducing viral transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion between the viral and host cell membranes, which is mediated by the viral spike protein. We have designed lipopeptide fusion inhibitors that block this critical first step of infection and, on the basis of in vitro efficacy and in vivo biodistribution, selected a dimeric form for evaluation in an animal model. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour cohousing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and thus may readily translate into safe and effective intranasal prophylaxis to reduce transmission of SARS-CoV-2. |Administration, Intranasal[MESH] |Animals[MESH] |COVID-19/prevention & control/*transmission/virology[MESH] |Chlorocebus aethiops[MESH] |Disease Models, Animal[MESH] |Drug Design[MESH] |Ferrets[MESH] |Lipopeptides/*administration & dosage/chemistry/pharmacokinetics/pharmacology[MESH] |Membrane Fusion/*drug effects[MESH] |Mice[MESH] |Pre-Exposure Prophylaxis[MESH] |SARS-CoV-2/*drug effects/isolation & purification/physiology[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Tissue Distribution[MESH] |Vero Cells[MESH] |Viral Fusion Protein Inhibitors/*administration & dosage/chemistry/pharmacokinetics/pharmacology[MESH]Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-(epmc).pdf DeepDyve Pubget Overpricing