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10.1016/j.ahj.2021.02.008

http://scihub22266oqcxt.onion/10.1016/j.ahj.2021.02.008
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33596412!ä!33596412

suck abstract from ncbi


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pmid33596412      Am+Heart+J 2021 ; 235 (ä): 158-162
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  • Modified design of stimulation of the left ventricular endocardium for cardiac resynchronization therapy in nonresponders, previously untreatable and high-risk upgrade patients (SOLVE-CRT) trial #MMPMID33596412
  • Singh JP; Walsh MN; Kubo SH; Auricchio A; Delnoy PP; Gold MR; Sanders P; Lindenfeld J; Rinaldi CA; Ullery S
  • Am Heart J 2021[May]; 235 (ä): 158-162 PMID33596412show ga
  • The WiSE system is a novel, leadless endocardial system that can provide cardiac resynchronization therapy in patients who cannot be treated with a conventional epicardial left ventricular lead. Safety and efficacy were being evaluated in the pivotal, randomized, double-blind SOLVE-CRT Trial (Stimulation of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy.) The trial was initiated in 2018; however, patient enrollment was significantly impacted by the COVID-19 pandemic necessitating a change in design. This article describes the revised trial and the scientific rationale for the specific changes in the protocol.
  • |*COVID-19/epidemiology[MESH]
  • |*Cardiac Resynchronization Therapy/adverse effects/methods[MESH]
  • |*Endocardium[MESH]
  • |*Heart Failure/therapy[MESH]
  • |*Pandemics[MESH]
  • |Double-Blind Method[MESH]
  • |Humans[MESH]
  • |Multicenter Studies as Topic[MESH]
  • |Prospective Studies[MESH]
  • |Randomized Controlled Trials as Topic[MESH]
  • |Sample Size[MESH]
  • |Time Factors[MESH]
  • |Treatment Outcome[MESH]


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