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10.1016/j.celrep.2021.108790 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108790 33596407!7874916!33596407     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 34 (9): 108790 Nephropedia Template TP {{tp|p=33596407|t=2021. Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2 |pdf=|usr=}}{{33596407}} gab.com Text Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33596407 #FOAvip Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from patients with COVID-19 decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M, or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of immunoglobulin M (IgM). Twit Text FOAVip Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33596407 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33596407 #FOAvip English Wikipedia <ref>{{Cite pmid|33596407}}</ref> Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2 #MMPMID33596407 Gasser R; Cloutier M; Prevost J; Fink C; Ducas E; Ding S; Dussault N; Landry P; Tremblay T; Laforce-Lavoie A; Lewin A; Beaudoin-Bussieres G; Laumaea A; Medjahed H; Larochelle C; Richard J; Dekaban GA; Dikeakos JD; Bazin R; Finzi A Cell Rep 2021[Mar]; 34 (9): 108790 PMID33596407show ga Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from patients with COVID-19 decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M, or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of immunoglobulin M (IgM). |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/epidemiology/immunology/*therapy[MESH] |Canada/epidemiology[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Immunity, Humoral/immunology[MESH] |Immunization, Passive/methods[MESH] |Immunoglobulin A/immunology[MESH] |Immunoglobulin G/immunology[MESH] |Immunoglobulin M/blood/*immunology/*therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Major role of IgM in the neutralizing activity of convalescent plasma (epmc).pdf DeepDyve Pubget Overpricing