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10.1371/journal.pone.0237480 http://scihub22266oqcxt.onion/10.1371/journal.pone.0237480 33596218!7888609!33596218     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (2): e0237480 Nephropedia Template TP {{tp|p=33596218|t=2021. Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro |pdf=|usr=}}{{33596218}} gab.com Text Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33596218 #FOAvip In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remains a significant public health threat. Attachment and entry of coronaviruses including SARS-CoV-2 is mainly mediated by the spike glycoprotein. Here, we show that iota-carrageenan can inhibit the cell entry of the SARS-CoV-2 spike pseudotyped lentivirus in a dose dependent manner. SARS-CoV-2 spike pseudotyped lentivirus particles were efficiently neutralized with an IC50 value of 2.6 mug/ml iota-carrageenan. Experiments with patient isolated wild type SARS-CoV-2 virus showed an inhibition of replication in a similar range. In vitro data on iota-carrageenan against various Rhino- and endemic Coronaviruses showed similar IC50 values and translated readily into clinical effectiveness when a nasal spray containing iota-carrageenan demonstrated a reduction of severity and duration of symptoms of common cold caused by various respiratory viruses. Accordingly, our in vitro data on SARS-CoV-2 spike pseudotyped lentivirus and replication competent SARS-CoV-2 suggest that administration of iota-carrageenan may be an effective and safe prophylaxis or treatment for SARS-CoV-2 infections. Twit Text FOAVip Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33596218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33596218 #FOAvip English Wikipedia <ref>{{Cite pmid|33596218}}</ref> Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro #MMPMID33596218 Morokutti-Kurz M; Froba M; Graf P; Grosse M; Grassauer A; Auth J; Schubert U; Prieschl-Grassauer E PLoS One 2021[]; 16 (2): e0237480 PMID33596218show ga In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remains a significant public health threat. Attachment and entry of coronaviruses including SARS-CoV-2 is mainly mediated by the spike glycoprotein. Here, we show that iota-carrageenan can inhibit the cell entry of the SARS-CoV-2 spike pseudotyped lentivirus in a dose dependent manner. SARS-CoV-2 spike pseudotyped lentivirus particles were efficiently neutralized with an IC50 value of 2.6 mug/ml iota-carrageenan. Experiments with patient isolated wild type SARS-CoV-2 virus showed an inhibition of replication in a similar range. In vitro data on iota-carrageenan against various Rhino- and endemic Coronaviruses showed similar IC50 values and translated readily into clinical effectiveness when a nasal spray containing iota-carrageenan demonstrated a reduction of severity and duration of symptoms of common cold caused by various respiratory viruses. Accordingly, our in vitro data on SARS-CoV-2 spike pseudotyped lentivirus and replication competent SARS-CoV-2 suggest that administration of iota-carrageenan may be an effective and safe prophylaxis or treatment for SARS-CoV-2 infections. |Animals[MESH] |Antibodies, Viral/immunology[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/immunology/metabolism/*virology[MESH] |Carrageenan/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Lentivirus/metabolism[MESH] |Middle Aged[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Spike Glycoprotein, Coronavirus/immunology/metabolism[MESH] |Vero Cells[MESH] |Virus Internalization/drug effects[MESH]Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication(epmc).pdf DeepDyve Pubget Overpricing