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10.1016/j.medcli.2020.12.006 http://scihub22266oqcxt.onion/10.1016/j.medcli.2020.12.006 33593634!7843095!33593634     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33593634&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Med+Clin+(Barc) 2021 ; 156 (11): 541-546 Nephropedia Template TP {{tp|p=33593634|t=2021. Reduced retinal vessel density in COVID-19 patients and elevated D-dimer levels during the acute phase of the infection |pdf=|usr=}}{{33593634}} gab.com Text Reduced retinal vessel density in COVID-19 patients and elevated D-dimer levels during the acute phase of the infection JO: Med Clin (Barc) http://www.kidney.de/pget.php?&tw=1&pmid=33593634 #FOAvip PURPOSE: To describe macular vessel density and perfusion in COVID-19 patients using coherence tomography angiography (OCTA) and to investigate whether there is a correlation between retinal vascular abnormalities and clinical and laboratory parameters. METHODS: Cross-sectional analysis conducted at the Hospital Clinico San Carlos in Madrid, Spain. Patients with laboratory-confirmed COVID-19 that were attended in the Emergency Department (ED) from March 23 to March 29, 2020 were included. Fundus examination and OCTA were performed 4 weeks after being attended in ED. Macular OCTA parameters were analyzed and correlated with clinical (severity and hypoxemia- oxygen saturation<92%) and laboratory parameters during hospital stay (D-Dimer-DD, lactate dehydrogenase-LDH and C-reactive protein-CRP). RESULTS: 80 patients were included, mean age 55(SD9) years old; 46.3% male. We reported macular vessel density and perfusion measurements in COVID-19 patients. Those patients with D-Dimer>/=500ng/ml during SARS-CoV-2 infection had a decrease of central vessel density (mean difference 2.2; 95%CI 0.4-3.9) and perfusion density (mean difference 4.9; 95%CI 0.9-8.9) after the acute phase of COVID-19. These variations of vessel density and perfusion density were not documented in patients with LDH>/=500U/L, CRP>/=10mg/L and hypoxemia. CONCLUSIONS: COVID-19 patients showed short-term retinal vasculature abnormalities which may be related to a prothrombotic state associated with SARS-CoV-2 infection. Since the retinal microvasculature shares many morphological and physiological properties with the vasculature of other vital organs, further research is needed to establish whether patients with increased D-Dimer levels require more careful assessment and follow-up after COVID-19. Twit Text FOAVip Reduced retinal vessel density in COVID-19 patients and elevated D-dimer levels during the acute phase of the infection ????Med Clin (Barc) http://www.kidney.de/pget.php?&tw=1&pmid=33593634 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33593634 #FOAvip English Wikipedia <ref>{{Cite pmid|33593634}}</ref> Reduced retinal vessel density in COVID-19 patients and elevated D-dimer levels during the acute phase of the infection #MMPMID33593634 Guemes-Villahoz N; Burgos-Blasco B; Vidal-Villegas B; Donate-Lopez J; Martin-Sanchez FJ; Porta-Etessam J; Lopez-Guajardo L; Martin JLR; Gonzalez-Armengol JJ; Garcia-Feijoo J Med Clin (Barc) 2021[Jun]; 156 (11): 541-546 PMID33593634show ga PURPOSE: To describe macular vessel density and perfusion in COVID-19 patients using coherence tomography angiography (OCTA) and to investigate whether there is a correlation between retinal vascular abnormalities and clinical and laboratory parameters. METHODS: Cross-sectional analysis conducted at the Hospital Clinico San Carlos in Madrid, Spain. Patients with laboratory-confirmed COVID-19 that were attended in the Emergency Department (ED) from March 23 to March 29, 2020 were included. Fundus examination and OCTA were performed 4 weeks after being attended in ED. Macular OCTA parameters were analyzed and correlated with clinical (severity and hypoxemia- oxygen saturation<92%) and laboratory parameters during hospital stay (D-Dimer-DD, lactate dehydrogenase-LDH and C-reactive protein-CRP). RESULTS: 80 patients were included, mean age 55(SD9) years old; 46.3% male. We reported macular vessel density and perfusion measurements in COVID-19 patients. Those patients with D-Dimer>/=500ng/ml during SARS-CoV-2 infection had a decrease of central vessel density (mean difference 2.2; 95%CI 0.4-3.9) and perfusion density (mean difference 4.9; 95%CI 0.9-8.9) after the acute phase of COVID-19. These variations of vessel density and perfusion density were not documented in patients with LDH>/=500U/L, CRP>/=10mg/L and hypoxemia. CONCLUSIONS: COVID-19 patients showed short-term retinal vasculature abnormalities which may be related to a prothrombotic state associated with SARS-CoV-2 infection. Since the retinal microvasculature shares many morphological and physiological properties with the vasculature of other vital organs, further research is needed to establish whether patients with increased D-Dimer levels require more careful assessment and follow-up after COVID-19. |*COVID-19[MESH] |Child[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Fibrin Fibrinogen Degradation Products[MESH] |Fluorescein Angiography[MESH] |Humans[MESH] |Male[MESH] |Retinal Vessels/diagnostic imaging[MESH] |SARS-CoV-2[MESH] |Spain[MESH]Reduced retinal vessel density in COVID-19 patients and elevated D-dim(epmc).pdf DeepDyve Pubget Overpricing