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10.1016/j.ijid.2021.02.038 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.02.038 33592338!7881292!33592338     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 105 (ä): 307-311 Nephropedia Template TP {{tp|p=33592338|t=2021. Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies |pdf=|usr=}}{{33592338}} gab.com Text Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33592338 #FOAvip The design of human challenge studies balances scientific validity, efficiency and study safety. This Perspective explores some advantages and disadvantages of 'low-dosage' challenge studies, in the setting of testing second-generation vaccines against COVID-19. Compared with a conventional vaccine challenge, a low-dosage vaccine challenge would be more likely to start, and start earlier. A low-dosage challenge would also be less likely to rule out a vaccine candidate that would have potentially been effective, particularly in certain target uses. A key ethical advantage of a low-dosage challenge over a conventional challenge is that both it and its dose escalation process are safer for each participant. Low-dosage studies would require larger numbers of participants than conventional challenges, but this and other potential disadvantages are less serious than they may initially appear. Overall, low-dosage challenges should be considered for certain roles such as prioritizing between second-generation vaccines against COVID-19. Twit Text FOAVip Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33592338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33592338 #FOAvip English Wikipedia <ref>{{Cite pmid|33592338}}</ref> Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies #MMPMID33592338 Steuwer B; Jamrozik E; Eyal N Int J Infect Dis 2021[Apr]; 105 (ä): 307-311 PMID33592338show ga The design of human challenge studies balances scientific validity, efficiency and study safety. This Perspective explores some advantages and disadvantages of 'low-dosage' challenge studies, in the setting of testing second-generation vaccines against COVID-19. Compared with a conventional vaccine challenge, a low-dosage vaccine challenge would be more likely to start, and start earlier. A low-dosage challenge would also be less likely to rule out a vaccine candidate that would have potentially been effective, particularly in certain target uses. A key ethical advantage of a low-dosage challenge over a conventional challenge is that both it and its dose escalation process are safer for each participant. Low-dosage studies would require larger numbers of participants than conventional challenges, but this and other potential disadvantages are less serious than they may initially appear. Overall, low-dosage challenges should be considered for certain roles such as prioritizing between second-generation vaccines against COVID-19. |*Clinical Trials as Topic[MESH] |*Research Design[MESH] |Biomedical Research/methods[MESH] |COVID-19 Vaccines/*administration & dosage[MESH] |COVID-19/*prevention & control[MESH] |Humans[MESH]Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage (epmc).pdf DeepDyve Pubget Overpricing