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10.1016/j.meegid.2021.104772 http://scihub22266oqcxt.onion/10.1016/j.meegid.2021.104772 33592317!7882217!33592317     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Genet+Evol 2021 ; 90 (ä): 104772 Nephropedia Template TP {{tp|p=33592317|t=2021. Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing minor variant reactivation |pdf=|usr=}}{{33592317}} gab.com Text Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing minor variant reactivation JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=33592317 #FOAvip Different groups have recently reported events of SARS-CoV-2 reinfection, where patients had a sequence of positive-negative-positive RT-PCR tests. However, such events could be explained by different scenarios such as intermittent viral shedding, bonafide re-infection or multiple infection with alternating predominance of different viruses. Analysis of minor variants is an important tool to distinguish between these scenarios. Using ARTIC network PCR amplification and next-generation sequencing, we obtained SARS-CoV-2 sequences from two timepoints (with a time span of 102 days) of a patient followed at the Brazilian National Cancer Institute. Within-host variant analysis evidenced three single nucleotide variants (SNVs) at the consensus viral sequence in the second timepoint that were already present in the first timepoint as minor variants. Another five SNVs found in the second timepoint were not detected in the first sample sequenced, suggesting an additional infection by a yet another new virus. Our observation shed light into the existence of different viral populations that are present in dynamic frequencies and fluctuate during the course of SARS-CoV-2 infection. The detection of these variants in distinct disease events of an individual highlights a complex interplay between viral reactivation from a pre-existing minority variant and reinfection by a different virus. Twit Text FOAVip Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing minor variant reactivation ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=33592317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33592317 #FOAvip English Wikipedia <ref>{{Cite pmid|33592317}}</ref> Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing minor variant reactivation #MMPMID33592317 Siqueira JD; Goes LR; Alves BM; da Silva ACP; de Carvalho PS; Cicala C; Arthos J; Viola JPB; Soares MA Infect Genet Evol 2021[Jun]; 90 (ä): 104772 PMID33592317show ga Different groups have recently reported events of SARS-CoV-2 reinfection, where patients had a sequence of positive-negative-positive RT-PCR tests. However, such events could be explained by different scenarios such as intermittent viral shedding, bonafide re-infection or multiple infection with alternating predominance of different viruses. Analysis of minor variants is an important tool to distinguish between these scenarios. Using ARTIC network PCR amplification and next-generation sequencing, we obtained SARS-CoV-2 sequences from two timepoints (with a time span of 102 days) of a patient followed at the Brazilian National Cancer Institute. Within-host variant analysis evidenced three single nucleotide variants (SNVs) at the consensus viral sequence in the second timepoint that were already present in the first timepoint as minor variants. Another five SNVs found in the second timepoint were not detected in the first sample sequenced, suggesting an additional infection by a yet another new virus. Our observation shed light into the existence of different viral populations that are present in dynamic frequencies and fluctuate during the course of SARS-CoV-2 infection. The detection of these variants in distinct disease events of an individual highlights a complex interplay between viral reactivation from a pre-existing minority variant and reinfection by a different virus. |*Host-Pathogen Interactions[MESH] |*Reinfection[MESH] |*SARS-CoV-2/physiology[MESH] |Aged[MESH] |Biomarkers[MESH] |COVID-19/*diagnosis/*virology[MESH] |Comorbidity[MESH] |Disease Susceptibility[MESH] |Fatal Outcome[MESH] |Humans[MESH] |Male[MESH] |Tomography, X-Ray Computed[MESH] |Viral Load[MESH]Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing mino(epmc).pdf DeepDyve Pubget Overpricing