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10.1371/journal.pone.0247163

http://scihub22266oqcxt.onion/10.1371/journal.pone.0247163
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33592050!7886121!33592050
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suck abstract from ncbi


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pmid33592050      PLoS+One 2021 ; 16 (2): e0247163
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  • Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study #MMPMID33592050
  • Behera P; Patro BK; Singh AK; Chandanshive PD; S R R; Pradhan SK; Pentapati SSK; Batmanabane G; Mohapatra PR; Padhy BM; Bal SK; Singh SR; Mohanty RR
  • PLoS One 2021[]; 16 (2): e0247163 PMID33592050show ga
  • BACKGROUND: Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers. METHODS: A hospital-based matched case-control study was conducted among healthcare workers of AIIMS Bhubaneswar, India, from September to October 2020. Profession, gender, age and date of diagnosis were matched for 186 case-control pairs. Cases and controls were healthcare workers who tested positive and negative, respectively, for COVID-19 by RT-PCR. Exposure was defined as the intake of ivermectin and/or hydroxychloroquine and/or vitamin-C and/or other prophylaxis for COVID-19. Data collection and entry was done in Epicollect5, and analysis was performed using STATA version 13. Conditional logistic regression models were used to describe the associated factors for SARS-CoV-2 infection. RESULTS: Ivermectin prophylaxis was taken by 76 controls and 41 cases. Two-dose ivermectin prophylaxis (AOR 0.27, 95% CI, 0.15-0.51) was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Those involved in physical activity (AOR 3.06 95% CI, 1.18-7.93) for more than an hour/day were more likely to contract SARS-CoV-2 infection. Type of household, COVID duty, single-dose ivermectin prophylaxis, vitamin-C prophylaxis and hydroxychloroquine prophylaxis were not associated with SARS-CoV-2 infection. CONCLUSION: Two-dose ivermectin prophylaxis at a dose of 300 mug/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.
  • |Adult[MESH]
  • |Ascorbic Acid/administration & dosage/therapeutic use[MESH]
  • |COVID-19/epidemiology/*prevention & control[MESH]
  • |Case-Control Studies[MESH]
  • |Chemoprevention/methods[MESH]
  • |Drug Combinations[MESH]
  • |Female[MESH]
  • |Health Personnel/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |India[MESH]
  • |Ivermectin/administration & dosage/*therapeutic use[MESH]
  • |Male[MESH]


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