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10.1007/82_2020_230

http://scihub22266oqcxt.onion/10.1007/82_2020_230
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33591423!ä!33591423

suck abstract from ncbi

pmid33591423      Curr+Top+Microbiol+Immunol 2022 ; 440 (ä): 1-30
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  • mRNA-Based Vaccines and Mode of Action #MMPMID33591423
  • Gergen J; Petsch B
  • Curr Top Microbiol Immunol 2022[]; 440 (ä): 1-30 PMID33591423show ga
  • In the past 20 years, the mRNA vaccine technology has evolved from the first proof of concept to the first licensed vaccine against emerging pandemics such as SARS-CoV-2. Two mRNA vaccines targeting SARS-CoV-2 have received emergency use authorization by US FDA, conditional marketing authorization by EMA, as well as multiple additional national regulatory authorities. The simple composition of an mRNA encoding the antigen formulated in a lipid nanoparticle enables a fast adaptation to new emerging pathogens. This can speed up vaccine development in pandemics from antigen and sequence selection to clinical trial to only a few months. mRNA vaccines are well tolerated and efficacious in animal models for multiple pathogens and will further contribute to the development of vaccines for other unaddressed diseases. Here, we give an overview of the mRNA vaccine design and factors for further optimization of this new promising technology and discuss current knowledge on the mode of action of mRNA vaccines interacting with the innate and adaptive immune system.
  • |*Vaccine Development[MESH]
  • |*mRNA Vaccines/pharmacology[MESH]
  • |Animals[MESH]
  • |COVID-19 Vaccines[MESH]
  • |COVID-19/prevention & control[MESH]


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