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Deprecated: Implicit conversion from float 334.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Scand+J+Clin+Lab+Invest 2021 ; 81 (3): 187-193 Nephropedia Template TP
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Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies A multicenter study in Spain (BIOCOVID-Spain study) #MMPMID33591234
Garcia de Guadiana-Romualdo L; Morell-Garcia D; Morales-Indiano C; Bauca JM; Alcaide Martin MJ; Esparza Del Valle C; Gutierrez Revilla JI; Urrechaga E; Alamo JM; Hernando Holgado AM; Lorenzo-Lozano MC; Sanchez Fdez-Pacheco S; de la Hera Cagigal P; Juncos Tobarra MA; Vilchez JA; Virseda Chamorro I; Gutierrez Garcia I; Pastor Murcia Y; Sahuquillo Frias L; Altimira Queral L; Nuez-Zaragoza E; Adell Ruiz de Leon J; Ruiz Ripa A; Salas Gomez-Pablos P; Cebreiros Lopez I; Fernandez Uriarte A; Larruzea A; Lopez Yepes ML; Esteban Torrella P; Zamorano Andres MC; Pedregosa Diaz J; Acevedo Alcaraz C; Blazquez-Manzanera AL; Padilla Jimenez AML; Baamonde Calzada MC; Vera M; Chafer Rudilla M; Canalda Campas M; Garcia Munoz S; Vicente Gutierrez L; Jimenez Anon L; Perez Martinez A; Pons Castillo A; Gonzalez Tamayo R; Ferriz Vivancos J; Rodriguez-Fraga O; Ferrer Diaz de Brito Fernandez V; Aguadero V; Garcia Arevalo MG; Arnaldos Carrillo M; Gonzalez Morales M; Nunez Garate M; Ruiz Iruela C; Sancho-Rodriguez N; Vila Perez M; Egea-Caparros JM; Saenz L; Blasco Barbero A; Galan Ortega A
Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.