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10.1097/INF.0000000000003088

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33591078!ä!33591078

suck abstract from ncbi


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pmid33591078      Pediatr+Infect+Dis+J 2021 ; 40 (5): e185-e188
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  • High Rates of SARS-CoV-2 Family Transmission in Children of Healthcare Workers During the First Pandemic Wave in Madrid, Spain: Serologic Study #MMPMID33591078
  • Mendez-Echevarria A; Sainz T; de Felipe B; Alcolea S; Olbrich P; Goycochea-Valdivia WA; Escosa-Garcia L; Cobo L; Calvo C; Neth O
  • Pediatr Infect Dis J 2021[May]; 40 (5): e185-e188 PMID33591078show ga
  • BACKGROUND: Data on SARS-CoV-2 transmission among children living with healthcare workers (HCWs) are scarce. METHODS: A cross-sectional study was performed at a tertiary Hospital in Madrid, including children of HCW who suffered from SARS-CoV-2 infection between March and May 2020. Children underwent enzyme-linked immunosorbent serological study for detecting SARS-CoV-2 antibodies: VIRCELL IgG assay. RESULTS: One hundred thirteen children from 69 HCWs with confirmed SARS-CoV-2 infection were recruited: 47 children had positive IgG (41.6%). Children secondary attack rate was 43.7% (25% if both parents have had asymptomatic infection; 39.5% if one parent was symptomatic; and 47% when both parents had symptoms). Having a positive sibling was associated with a positive IgG result (odds ratio = 12.2; 95% confidence interval: 4.4-33.7, P < 0.001). Median age was higher in IgG positive children (P = 0.022). Children who referred anosmia presented higher IgG titles (P < 0.04). CONCLUSIONS: We observed a very high SARS-CoV-2 transmission in children of HCW during the first pandemic wave, especially when both parents were symptomatic. Having a positive sibling was associated with seroconversion, supporting the important role of family clusters in the transmission of SARS-CoV-2.
  • |*Health Personnel[MESH]
  • |Adolescent[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Asymptomatic Infections/epidemiology[MESH]
  • |COVID-19/diagnosis/epidemiology/*transmission[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Disease Transmission, Infectious[MESH]
  • |Family[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood[MESH]
  • |Infectious Disease Transmission, Patient-to-Professional[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Seroconversion[MESH]
  • |Spain/epidemiology[MESH]


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  • suck abstract from ncbi

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