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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biosci+Biotechnol+Biochem 2021 ; 85 (5): 1170-1174 Nephropedia Template TP
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In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor #MMPMID33590853
Ando T; Yamamoto M; Takamori Y; Tsukamoto K; Fuji D; Kawakami T
Biosci Biotechnol Biochem 2021[Apr]; 85 (5): 1170-1174 PMID33590853show ga
Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6.