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10.1093/bbb/zbaa124

http://scihub22266oqcxt.onion/10.1093/bbb/zbaa124
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33590853!7799299!33590853
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suck abstract from ncbi


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pmid33590853      Biosci+Biotechnol+Biochem 2021 ; 85 (5): 1170-1174
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  • In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor #MMPMID33590853
  • Ando T; Yamamoto M; Takamori Y; Tsukamoto K; Fuji D; Kawakami T
  • Biosci Biotechnol Biochem 2021[Apr]; 85 (5): 1170-1174 PMID33590853show ga
  • Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aptamers, Nucleotide/chemistry/*therapeutic use[MESH]
  • |Base Sequence[MESH]
  • |COVID-19/complications[MESH]
  • |Cytokine Release Syndrome/*drug therapy/etiology[MESH]
  • |DNA, Viral/drug effects[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*antagonists & inhibitors/metabolism[MESH]
  • |Receptors, Interleukin-6/*antagonists & inhibitors/metabolism[MESH]


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