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10.1093/rheumatology/keab157 http://scihub22266oqcxt.onion/10.1093/rheumatology/keab157 33590837!7928620!33590837     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rheumatology+(Oxford) 2021 ; 60 (9): 4418-4427 Nephropedia Template TP {{tp|p=33590837|t=2021. Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression |pdf=|usr=}}{{33590837}} gab.com Text Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression JO: Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=33590837 #FOAvip OBJECTIVES: The biomarkers of an immunological dysregulation due to a chronic HBV infection are indeed understudied. If untreated, this condition may evolve into liver impairment co-occurring with extrahepatic involvements. Here, we aim to identify a new panel of biomarkers [including immunoglobulin G (IgG) subclasses, RF, and Free Light Chains (FLCs)] that may be useful and reliable for clinical evaluation of HBV-related cryoglobulinemia. METHODS: We retrospectively analysed clinical data from 44 HBV-positive patients. The patients were stratified (according to the presence/absence of mixed cryoglobulinemia) into two groups: 22 with cryoglobulins (CGs) and 22 without CGs. Samples from 20 healthy blood donors (HDs) were used as negative controls. Serum samples were tested for IgG subclasses, RF (-IgM, -IgG, and -IgA type), and FLCs. RESULTS: We detected a strikingly different distribution of serum IgG subclasses between HDs and HBV-positive patients, together with different RF isotypes; in addition, FLCs were significantly increased in HBV-positive patients compared with HDs, while no significant difference was shown between HBV-positive patients with/without mixed cryoglobulinemia. CONCLUSION: The immune-inflammatory response triggered by HBV may be monitored by a peculiar profile of biomarkers. Our results open a new perspective in the precision medicine era; in these challenging times, they could also be employed to monitor the clinical course of those COVID-19 patients who are at high risk of HBV reactivation due to liver impairment and/or immunosuppressive therapies. Twit Text FOAVip Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression ????Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=33590837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33590837 #FOAvip English Wikipedia <ref>{{Cite pmid|33590837}}</ref> Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression #MMPMID33590837 Pocino K; Napodano C; Gragnani L; Ciasca G; Colantuono S; Marri S; Vantaggio L; Gulli F; Lorini S; Barini A; Stefanile A; Miele L; Casato M; Zignego AL; Rapaccini GL; Marino M; Visentini M; Basile U Rheumatology (Oxford) 2021[Sep]; 60 (9): 4418-4427 PMID33590837show ga OBJECTIVES: The biomarkers of an immunological dysregulation due to a chronic HBV infection are indeed understudied. If untreated, this condition may evolve into liver impairment co-occurring with extrahepatic involvements. Here, we aim to identify a new panel of biomarkers [including immunoglobulin G (IgG) subclasses, RF, and Free Light Chains (FLCs)] that may be useful and reliable for clinical evaluation of HBV-related cryoglobulinemia. METHODS: We retrospectively analysed clinical data from 44 HBV-positive patients. The patients were stratified (according to the presence/absence of mixed cryoglobulinemia) into two groups: 22 with cryoglobulins (CGs) and 22 without CGs. Samples from 20 healthy blood donors (HDs) were used as negative controls. Serum samples were tested for IgG subclasses, RF (-IgM, -IgG, and -IgA type), and FLCs. RESULTS: We detected a strikingly different distribution of serum IgG subclasses between HDs and HBV-positive patients, together with different RF isotypes; in addition, FLCs were significantly increased in HBV-positive patients compared with HDs, while no significant difference was shown between HBV-positive patients with/without mixed cryoglobulinemia. CONCLUSION: The immune-inflammatory response triggered by HBV may be monitored by a peculiar profile of biomarkers. Our results open a new perspective in the precision medicine era; in these challenging times, they could also be employed to monitor the clinical course of those COVID-19 patients who are at high risk of HBV reactivation due to liver impairment and/or immunosuppressive therapies. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/*blood[MESH] |COVID-19/*immunology[MESH] |Cryoglobulinemia/*immunology/*virology[MESH] |Disease Progression[MESH] |Female[MESH] |Hepatitis B virus/*immunology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Retrospective Studies[MESH]Solving the mystery of HBV-related mixed cryoglobulinemia: potential b(epmc).pdf DeepDyve Pubget Overpricing