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10.1080/00365521.2021.1881814

http://scihub22266oqcxt.onion/10.1080/00365521.2021.1881814
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33590789!ä!33590789

suck abstract from ncbi


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pmid33590789      Scand+J+Gastroenterol 2021 ; 56 (4): 453-457
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  • A Danish population-based case series of patients with liver cirrhosis and coronavirus disease 2019 #MMPMID33590789
  • Attauabi M; Burisch J; Bendtsen F; Kimer N
  • Scand J Gastroenterol 2021[Apr]; 56 (4): 453-457 PMID33590789show ga
  • OBJECTIVES: Coronavirus disease 2019 (COVID-19) is an ongoing major health emergency, but its occurrence and clinical impact on patients withliver cirrhosis is unknown. Therefore, we conducted a population-based study of 2.6 million Danish citizens investigating the occurrence and impact of COVID-19 in patients with liver cirrhosis. MATERIALS AND METHODS: A prospective population-based cohort study was conducted in the Capital Region of Denmark and Region Zealand in the study period between 1 March 2020 up until 31 May 2020, with the only eligibility criteria being a reverse-transcriptase polymerase chain reaction for presence of viral genomic material confirming COVID-19. The patients were subsequently stratified according to presence of pre-existing liver cirrhosis. RESULTS: Among 575,935 individuals tested, 1713 patients had a diagnosis of cirrhosis. COVID-19 occurredsignificantly lessamongpatients with cirrhosis (n = 15; 0.9%, p < .01) compared with the population without cirrhosis (n = 10,593; 1.8%). However, a large proportion (n = 6;40.0%) required a COVID-19 related hospitalization which was correlated with higher values of alanine aminotransferase (p < .01) and lactate dehydrogenase (p = .04). In addition, one-in-three (n = 2; 13.3%) required intensive therapy. Four patients died (26.7%) and mortality was associated with higher MELD scores, co-existing type 2 diabetes, and bacterial superinfections. CONCLUSION: In conclusion, patientswith cirrhosis may have a lower risk of COVID-19; but a higher risk of complications hereto and mortality.
  • |*COVID-19/epidemiology/prevention & control[MESH]
  • |*Liver Cirrhosis/blood/epidemiology/therapy[MESH]
  • |*Liver Function Tests/methods/statistics & numerical data[MESH]
  • |Alanine Transaminase/blood[MESH]
  • |COVID-19 Nucleic Acid Testing/statistics & numerical data[MESH]
  • |Cohort Studies[MESH]
  • |Denmark/epidemiology[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mortality[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]


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