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10.1038/s41591-021-01263-3 http://scihub22266oqcxt.onion/10.1038/s41591-021-01263-3 33589825!8315827!33589825     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2021 ; 27 (3): 454-462 Nephropedia Template TP {{tp|p=33589825|t=2021. Humoral signatures of protective and pathological SARS-CoV-2 infection in children |pdf=|usr=}}{{33589825}} gab.com Text Humoral signatures of protective and pathological SARS-CoV-2 infection in children JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33589825 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS-C). Identifying immune mechanisms that result in these disparate clinical phenotypes in children could provide critical insights into coronavirus disease 2019 (COVID-19) pathogenesis. Using systems serology, in this study we observed in 25 children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease. Conversely, IgA and neutrophil responses were significantly expanded in adults with severe disease. Moreover, weeks after the resolution of SARS-CoV-2 infection, children who develop MIS-C maintained highly inflammatory monocyte-activating SARS-CoV-2 IgG antibodies, distinguishable from acute disease in children but with antibody levels similar to those in convalescent adults. Collectively, these data provide unique insights into the potential mechanisms of IgG and IgA that might underlie differential disease severity as well as unexpected complications in children infected with SARS-CoV-2. Twit Text FOAVip Humoral signatures of protective and pathological SARS-CoV-2 infection in children ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33589825 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33589825 #FOAvip English Wikipedia <ref>{{Cite pmid|33589825}}</ref> Humoral signatures of protective and pathological SARS-CoV-2 infection in children #MMPMID33589825 Bartsch YC; Wang C; Zohar T; Fischinger S; Atyeo C; Burke JS; Kang J; Edlow AG; Fasano A; Baden LR; Nilles EJ; Woolley AE; Karlson EW; Hopke AR; Irimia D; Fischer ES; Ryan ET; Charles RC; Julg BD; Lauffenburger DA; Yonker LM; Alter G Nat Med 2021[Mar]; 27 (3): 454-462 PMID33589825show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS-C). Identifying immune mechanisms that result in these disparate clinical phenotypes in children could provide critical insights into coronavirus disease 2019 (COVID-19) pathogenesis. Using systems serology, in this study we observed in 25 children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease. Conversely, IgA and neutrophil responses were significantly expanded in adults with severe disease. Moreover, weeks after the resolution of SARS-CoV-2 infection, children who develop MIS-C maintained highly inflammatory monocyte-activating SARS-CoV-2 IgG antibodies, distinguishable from acute disease in children but with antibody levels similar to those in convalescent adults. Collectively, these data provide unique insights into the potential mechanisms of IgG and IgA that might underlie differential disease severity as well as unexpected complications in children infected with SARS-CoV-2. |Adolescent[MESH] |Adult[MESH] |Age of Onset[MESH] |Aged[MESH] |Antibodies, Neutralizing/analysis/blood[MESH] |Antibodies, Viral/analysis/*blood[MESH] |Asymptomatic Infections[MESH] |COVID-19/blood/*epidemiology/pathology[MESH] |Carrier State/blood/epidemiology[MESH] |Child[MESH] |Child, Preschool[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Immunity/physiology[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH] |Systemic Inflammatory Response Syndrome/blood/epidemiology[MESH]Humoral signatures of protective and pathological SARS-CoV-2 infection(epmc).pdf DeepDyve Pubget Overpricing