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10.1038/s42003-021-01754-6 http://scihub22266oqcxt.onion/10.1038/s42003-021-01754-6 33589648!7884689!33589648     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 228 Nephropedia Template TP {{tp|p=33589648|t=2021. Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants |pdf=|usr=}}{{33589648}} gab.com Text Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33589648 #FOAvip SARS-CoV-2 has been mutating since it was first sequenced in early January 2020. Here, we analyze 45,494 complete SARS-CoV-2 geneome sequences in the world to understand their mutations. Among them, 12,754 sequences are from the United States. Our analysis suggests the presence of four substrains and eleven top mutations in the United States. These eleven top mutations belong to 3 disconnected groups. The first and second groups consisting of 5 and 8 concurrent mutations are prevailing, while the other group with three concurrent mutations gradually fades out. Moreover, we reveal that female immune systems are more active than those of males in responding to SARS-CoV-2 infections. One of the top mutations, 27964C > T-(S24L) on ORF8, has an unusually strong gender dependence. Based on the analysis of all mutations on the spike protein, we uncover that two of four SASR-CoV-2 substrains in the United States become potentially more infectious. Twit Text FOAVip Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33589648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33589648 #FOAvip English Wikipedia <ref>{{Cite pmid|33589648}}</ref> Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants #MMPMID33589648 Wang R; Chen J; Gao K; Hozumi Y; Yin C; Wei GW Commun Biol 2021[Feb]; 4 (1): 228 PMID33589648show ga SARS-CoV-2 has been mutating since it was first sequenced in early January 2020. Here, we analyze 45,494 complete SARS-CoV-2 geneome sequences in the world to understand their mutations. Among them, 12,754 sequences are from the United States. Our analysis suggests the presence of four substrains and eleven top mutations in the United States. These eleven top mutations belong to 3 disconnected groups. The first and second groups consisting of 5 and 8 concurrent mutations are prevailing, while the other group with three concurrent mutations gradually fades out. Moreover, we reveal that female immune systems are more active than those of males in responding to SARS-CoV-2 infections. One of the top mutations, 27964C > T-(S24L) on ORF8, has an unusually strong gender dependence. Based on the analysis of all mutations on the spike protein, we uncover that two of four SASR-CoV-2 substrains in the United States become potentially more infectious. |5' Untranslated Regions/genetics[MESH] |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2/chemistry/metabolism[MESH] |COVID-19/*virology[MESH] |Evolution, Molecular[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Models, Molecular[MESH] |Mutation/*genetics[MESH] |Nucleocapsid/metabolism[MESH] |Open Reading Frames/genetics[MESH] |Polymorphism, Single Nucleotide/genetics[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |Protein Folding[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH] |Thermodynamics[MESH]Analysis of SARS-CoV-2 mutations in the United States suggests presenc(epmc).pdf DeepDyve Pubget Overpricing