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10.1016/j.bj.2020.11.011 http://scihub22266oqcxt.onion/10.1016/j.bj.2020.11.011 33589377!7685954!33589377     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+J 2021 ; 44 (1): 7-17 Nephropedia Template TP {{tp|p=33589377|t=2021. Neutralizing monoclonal antibodies for COVID-19 treatment and prevention |pdf=|usr=}}{{33589377}} gab.com Text Neutralizing monoclonal antibodies for COVID-19 treatment and prevention JO: Biomed J http://www.kidney.de/pget.php?&tw=1&pmid=33589377 #FOAvip The SARS-CoV-2 pandemic has caused unprecedented global health and economic crises. Several vaccine approaches and repurposed drugs are currently under evaluation for safety and efficacy. However, none of them have been approved for COVID-19 yet. Meanwhile, several nMAbs targeting SARS-CoV-2 spike glycoprotein are in different stages of development and clinical testing. Preclinical studies have shown that cocktails of potent nMAbs targeting the receptor binding site of SARS-CoV-2, as well as broad-nMAbs targeting conserved regions within the virus spike, might be effective for the treatment and prophylaxis of COVID-19. Currently, several clinical trials have started to test safety, tolerability, PKs and efficacy of these nMAbs. One paramount limitation for the use of nMAbs in clinical settings is the production of large amounts of MAbs and the high costs related to it. Cooperation among public and private institutions coupled with speed of development, rapid safety evaluation and efficacy, and early planning for scale-up and manufacture will be critical for the control of COVID-19 pandemic. Twit Text FOAVip Neutralizing monoclonal antibodies for COVID-19 treatment and prevention ????Biomed J http://www.kidney.de/pget.php?&tw=1&pmid=33589377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33589377 #FOAvip English Wikipedia <ref>{{Cite pmid|33589377}}</ref> Neutralizing monoclonal antibodies for COVID-19 treatment and prevention #MMPMID33589377 Jaworski JP Biomed J 2021[Mar]; 44 (1): 7-17 PMID33589377show ga The SARS-CoV-2 pandemic has caused unprecedented global health and economic crises. Several vaccine approaches and repurposed drugs are currently under evaluation for safety and efficacy. However, none of them have been approved for COVID-19 yet. Meanwhile, several nMAbs targeting SARS-CoV-2 spike glycoprotein are in different stages of development and clinical testing. Preclinical studies have shown that cocktails of potent nMAbs targeting the receptor binding site of SARS-CoV-2, as well as broad-nMAbs targeting conserved regions within the virus spike, might be effective for the treatment and prophylaxis of COVID-19. Currently, several clinical trials have started to test safety, tolerability, PKs and efficacy of these nMAbs. One paramount limitation for the use of nMAbs in clinical settings is the production of large amounts of MAbs and the high costs related to it. Cooperation among public and private institutions coupled with speed of development, rapid safety evaluation and efficacy, and early planning for scale-up and manufacture will be critical for the control of COVID-19 pandemic. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Antibodies, Monoclonal/adverse effects/*therapeutic use[MESH] |Antibodies, Neutralizing/*therapeutic use[MESH] |COVID-19/prevention & control[MESH] |Humans[MESH] |Pre-Exposure Prophylaxis[MESH]Neutralizing monoclonal antibodies for COVID-19 treatment and preventi(epmc).pdf DeepDyve Pubget Overpricing