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10.1016/j.bbrc.2021.02.016 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2021.02.016 33588235!7874949!33588235     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2021 ; 547 (ä): 23-28 Nephropedia Template TP {{tp|p=33588235|t=2021. EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro |pdf=|usr=}}{{33588235}} gab.com Text EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33588235 #FOAvip COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication. Twit Text FOAVip EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33588235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33588235 #FOAvip English Wikipedia <ref>{{Cite pmid|33588235}}</ref> EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro #MMPMID33588235 Jang M; Park R; Park YI; Cha YE; Yamamoto A; Lee JI; Park J Biochem Biophys Res Commun 2021[Apr]; 547 (ä): 23-28 PMID33588235show ga COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication. |Amino Acid Sequence[MESH] |Cell Line, Tumor[MESH] |Coronavirus 229E, Human/*drug effects/physiology[MESH] |Coronavirus 3C Proteases/antagonists & inhibitors[MESH] |Coronavirus OC43, Human/*drug effects/physiology[MESH] |Humans[MESH] |Polyphenols/*pharmacology[MESH] |SARS-CoV-2/drug effects/physiology[MESH] |Tea/*chemistry[MESH]EGCG, a green tea polyphenol, inhibits human coronavirus replication i(epmc).pdf DeepDyve Pubget Overpricing